Nanostructured Materials for the Biomedical, Pharmaceutical, & Cosmetic Markets

SUMMARY

INTRODUCTION

Nanotechnology has continued to develop rapidly in the 6 years since these three reports were published. In light of these developments, BCC Research decided to take a fresh look at the industry and reevaluate the existing and potential markets for nanoparticulate materials. The present report is an update of the 2001 report on biomedical, pharmaceutical, and cosmetic applications of nanoparticles.

There are a number of other published reports and studies covering various aspects of the market for nanoparticles and nanostructured materials. However, the literature lacks a comprehensive, up-to-date, and realistic technical market assessment that focuses on nanoparticles in biomedical, pharmaceutical, and cosmetic applications.

SCOPE OF STUDY

This report contains:

• Descriptions of various types of nanoparticles including nanoparticulate ceramics, metals, alloys, and semiconductors in the form of dry powders, liquid dispersions, coatings and bulk materials
• The current market status for nanoparticles, trends and forecasts for growth over the next 5 years
• Discussion of organic nanoparticles such as lipids and dendrimers that are expected to play a significant role in future applications
• Analysis of nanomaterials-related patents issued during the past 2 years
• Profiles of major and minor companies working with nanoparticles.

TABLE OF CONTENTS

• Nanostructured Materials for the Biomedical, Pharmaceutical, & Cosmetic Markets
• Chapter 1 - EXECUTIVE SUMMARY
  • Summary Table: TOTAL WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL AND COSMETIC APPLICATIONS, THROUGH 2012 ($ MILLIONS)
  • Summary Figure: TOTAL WORLD MARKET SHARE PROJECTIONS FOR BIOMEDICAL, PHARMACEUTICAL AND COSMETIC APPLICATIONS OF NANOPARTICLES, 2006-2012 (%)
• Chapter 2 - OVERVIEW
  • TERMINOLOGY
  • PRODUCTS AND PROPERTIES
• Table 1 SUMMARY OF PROPERTY CHANGES AT THE NANOCRYSTALLINE-SIZE SCALE
  • CATALYTIC
  • ELECTRICAL
  • MAGNETIC
    • Magnetic (Continued)
  • MECHANICAL
  • OPTICAL AND ELECTRONIC
• HISTORICAL BACKGROUND
  • HISTORICAL BACKGROUND (CONTINUED)
• Figure 1 TIMELINE OF INDUSTRY EVENTS, 1920-2000
• Chapter 3 - NANOPARTICLE TECHNOLOGIES
  • PARTICLE PRODUCTION
    • TECHNOLOGIES FOR PRODUCING INORGANIC NANOPARTICLES
  • Table 2 CLASSES OF INORGANIC NANOPARTICLE PRODUCTION METHODS
• Table 3 PARTICLE PRODUCTION TECHNOLOGIES AND COMPANIES USING THEM
• Table 3 (CONTINUED)
  • Gas-Phase Processing
    • Gas Condensation with Thermal Evaporation
    • Vacuum Evaporation on Running Liquids (VERL)
• Figure 2 SCHEMATIC OF THE MODIFIED VERL PROCESS TO PRODUCE METAL NANOSUSPENSIONS
  • Thermal Plasma Synthesis
  • Combustion Synthesis
• Wet-Chemical Processes
  • Chemical Precipitation
  • Hydrothermal Processing
  • Sol-Gel Processing
• Figure 3 SOL-GEL SYNTHESIS FLOW CHART
  • Solid-State Processes
    • High-Energy Milling
    • Mechanochemical Synthesis
• TECHNOLOGIES FOR PRODUCING ORGANIC NANOPARTICLES
  • Lipids
  • Dendrimers
• PRODUCING STABLE DISPERSIONS
• PRODUCTION OF COATINGS, COMPONENTS, AND DEVICES
  • COATINGS
    • Slurry-Coating Routes
    • Dip Coating
    • Spin Coating
    • Comparison with Vapor-Deposition Techniques
• Table 4 COMPARISON OF COATING TECHNOLOGIES
  • Electrophoretic Deposition
  • Jet-Printing Process
  • Thermal Spray Coating
  • Direct Production of Nanostructured Coatings and Bulk Solids
  • Electrodeposition
  • Amorphous Crystallization
• COMPONENTS AND DEVICES
  • Consolidation of Nanoparticles into Components
    • Three-Dimensional Gel Lamination
    • Dynamic-Magnetic Consolidation
    • Field-Assisted Sintering Techniques
    • Quasi-Isostatic Pressure Process
    • Shockwave Compaction
    • Sinter Forging
    • Severe Plastic Deformation
• SELF-ASSEMBLY OF NANOPARTICLES
  • "BRICKS-AND-MORTAR"APPROACH ORDERS GOLD PARTICLES
  • MICELLES ENABLE ASSEMBLY OF NANOLAMINATES
  • VIRAL BIOTEMPLATE ORGANIZES NANOMETAL PARTICLES INTO ARRAYS
  • MAGNETIC NANOPARTICLE DISPERSIONS SELF-ASSEMBLE INTO ORDERED ARRAYS
• U.S. PATENT ANALYSIS
  • Introduction
  • Trends by Country
  • Trends by Assignee
• Figure 4 U.S. PATENT TRENDS BY ASSIGNEE'S COUNTRY (NUMBER OF PATENTS ISSUED BETWEEN 10/15/2005 AND 10/15/2007)
• Figure 5 SHARES OF U.S. PATENTS BY ASSIGNEE (%)
• Table 5 COMPANIES AND INSTITUTIONS AWARDED TWO OR MORE NANOMATERIAL-RELATED PATENTS BETWEEN OCTOBER 15, 2005 AND OCTOBER 15, 2007
  • Trends by Emphasis: Production versus Application
• Figure 6 SHARES OF PATENTS ISSUED BY EMPHASIS (%)
• Chapter 4 - INDUSTRY STRUCTURE
  • PRODUCERS
• Table 6 COMPANIES WORLDWIDE INVOLVED IN NANOPARTICLE DEVELOPMENT OR PRODUCTION FOR BIOMEDICAL AND COSMETIC APPLICATIONS
• Table 7 (CONTINUED)
• Figure 7 GEOGRAPHICAL DISTRIBUTION OF COMPANIES INVOLVED IN NANOPARTICLE DEVELOPMENT OR PRODUCTION FOR BIOMEDICAL AND COSMETIC APPLICATIONS (%)
  • COMMERCIAL PRODUCTS
  • NANOPARTICLE PRICING
• Table 7 FACTORS THAT IMPACT THE PRICING OF NANOPARTICLES
  • COMMERCIALIZATION STRATEGIES
  • INTERNATIONAL COMPETITION
  • REGULATORY ENVIRONMENT
  • REGULATION IN THE U.S.
    • U.S. Food and Drug Administration
      • Medical Devices
      • Drugs and Biologicals
      • Combination Products
    • U.S. Environmental Protection Agency
      • Other Agencies
  • REGULATION OVERSEAS
• GOVERNMENT FUNDING
  • NATIONAL NANOTECHNOLOGY INITIATIVE (NNI)
• Table 8 NNI BUDGET REQUESTS FOR NATIONAL INSTITUTES OF HEALTH, 2004-2008 ($ MILLIONS)
• Figure 8 RECENT TRENDS IN U.S. NATIONAL NANOTECHNOLOGY INITIATIVE SPENDING ON BIOMEDICAL R&D NANOTECHNOLOGY RESEARCH, FY 2004-2008 (BUDGET REQUESTS IN $ MILLIONS)
  • THE ADVANCED TECHNOLOGY PROGRAM (ATP)
    • Background
    • Relevant Awards
• Table 9 ADVANCED TECHNOLOGY PROGRAM AWARDS RELATED TO BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS OF NANOPARTICLES, 1999-2008 ($ MILLIONS)
  • SMALL BUSINESS INNOVATION RESEARCH (SBIR) AND SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS
  • Background
  • Relevant Awards
• Table 10 RECIPIENTS OF THREE OR MORE NANOMATERIALS-RELATED PHASE I SBIR/STTR AWARDS, 1991-2007 (NUMBERS ARE LOWER-BOUNDS)
• Chapter 5 - WORLD MARKETS
  • INTRODUCTION
  • WORLD MARKETS OVERVIEW
    • OVERALL MARKET FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS
• Figure 9 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL AND COSMETIC APPLICATIONS, 2006-2012 ($ MILLIONS)
• Figure 10 WORLD MARKET FORECAST FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS, 2006-2012 (MILLION KG)
  • MARKET SEGMENTATION BY APPLICATION
    • Segmentation in Terms of Value
• Table 11 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY TYPE OF APPLICATION IN TERMS OF VALUE, THROUGH 2012 ($ MILLIONS)
• Table 11 (CONTINUED)
• Figure 11WORLD NANOPARTICLES MARKET SHARE PROJECTIONS BY APPLICATION, 2006-2012 (%)
  • Segmentation in Terms of Volume
• Table 12 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY APPLICATION IN TERMS OF VOLUME, THROUGH 2012 (KG)
  • MARKET SEGMENTATION BY MATERIAL TYPE
    • Segmentation in Terms of Value
• Table 13 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY MATERIAL TYPE IN TERMS OF VALUE, THROUGH 2012 ($ MILLIONS)
• Figure 12WORLD MARKET SHARE PROJECTIONS FOR NANOPARTICLES BY MATERIAL TYPE, 2006-2012 (%)
  • Segmentation in Terms of Volume
• Table 14 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY MATERIAL TYPE IN TERMS OF VOLUME, THROUGH 2012 (KG)
  • DETAILED MARKET ANALYSIS
    • ANTIMICROBIAL MATERIALS
      • Background
      • Materials, Production, and Technical Requirements
      • Commercial and Regulatory Status
        • Antimicrobial Materials
• Table 15 ANTIMICROBIAL PRODUCTS INCORPORATING SILVER NANOPARTICLES
  • Nucryst Pharmaceuticals
  • Surfacine Development Co.
  • Try Co.
  • Fraunhofer Institute
  • Mineral Supplements
• World Markets
• Figure 13 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE SILVER USED IN ANTIMICROBIAL APPLICATIONS, 2006-2012 ($ MILLIONS)
  • Antimicrobial Dressings
• Table 16 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE SILVER, THROUGH 2012 (KG/$ MILLIONS)
  • Dietary Supplements
• BIOLOGICAL DETECTION AND LABELING
  • Background
  • Materials, Production, and Technical Requirements
• Table 17 BASIC REQUIREMENTS OF DIAGNOSTIC TESTS
  • Commercial and Regulatory Status
    • Established Applications
      • Colloidal Gold
• Table 18 RAPID DIAGNOSTIC TESTS THAT USE GOLD NANOPARTICLES AS LABELS
  • Nanoprobes, Inc.
  • Orasure Technologies, Inc.
  • Dendrimers
  • Emerging Technologies and Applications
• Table 19 EMERGING NANOPARTICLE-BASED TECHNOLOGIES FOR BIODETECTION AND LABELING BY COMPANY
• Table 20 COMPARISON OF VARIOUS TYPES OF EMERGING NANOPARTICULATE LABELING TECHNOLOGIES
  • BioCrystal, Ltd.
  • Evident Technologies
  • MagnaBioSciences, LLC
  • Microcosm, Inc.
  • Nanocrystal Technologies, LP
  • Nanosphere, Inc.
  • NymoxPharmaceutical Corp.
  • Quantum Dot Corp.
• Table 21 COMPARISON BETWEEN QDOTS AND CONVENTIONAL ORGANIC DYES
  • World Markets
• Table 22 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIODETECTION AND LABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)
• Figure 14 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICLES USED IN BIODETECTION AND LABELING APPLICATIONS, 2006-2012 ($ MILLIONS)
  • Colloidal Gold
• Table 23 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE GOLD USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)
  • Dendrimers
• Table 24 WORLD MARKET PROJECTIONS FOR DENDRIMERS USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)
• Semiconductor Nanoparticles
• Table 25 WORLD MARKETPROJECTIONS FOR SEMICONDUCTOR NANOPARTICLES USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)
  • Superparamagnetic Particles
• Table 26 WORLD MARKET PROJECTIONS FOR SUPERPARAMAGNETIC NANOPARTICLES USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)
  • BIOMAGNETIC SEPARATIONS
    • Background
    • Materials, Production, and Technical Requirements
      • Commercial and Regulatory Status
• Table 27 PRODUCERS OF SUPERPARAMAGNETIC MICROSPHERES FOR BIOLOGICAL SEPARATION APPLICATIONS
  • World Markets
• Table 28 WORLD MARKETS FOR IRON OXIDE NANOPARTICLES IN BIOMAGNETIC SEPARATIONS, THROUGH 2012 (KG/$ MILLIONS)
• Figure 15 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE IRON OXIDE USED IN BIOSEPARATION APPLICATIONS, 2006-2012 ($ MILLIONS)
  • DRUG DELIVERY
    • Background
• Table 29 CRITERIA FOR A NANOPARTICULATE DRUG DELIVERY VEHICLE
  • Materials, Production, and Technical Requirements
  • Commercial and Regulatory Status
• Table 30 COMPANIES ACTIVE IN THE DEVELOPMENT OF NANOPARTICLES FOR DRUG-DELIVERY APPLICATIONS
  • Cytimmune Sciences
• Table 31 TIMELINE OF NEW DRUG DEVELOPMENT PROCESS
  • PowderMed, Ltd.
  • SkyePharma
  • Starpharma
  • World Markets
• Table 32 WORLD MARKET PROJECTIONS FOR DENDRIMER-BASED DRUG DELIVERY SYSTEMS, THROUGH 2012 (KG/$ MILLIONS)
  • MAGNETIC RESONANCE IMAGING (MRI) CONTRAST AGENTS
    • Background
• Table 33 TYPES OF CONTRAST AGENTS USED FOR MRI IMAGING
  • Materials, Production, and Technical Requirements
• Commercial and Regulatory Status
• Table 34 SUPERPARAMAGNETIC IRON OXIDE CONTRAST MEDIA: REGULATORY AND MARKETING STATUS
  • World Markets
• Table 35 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE IRON OXIDE USED IN MRI CONTRAST MEDIA, THROUGH 2012 (KG/$ MILLIONS)
• Figure 16 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE IRON OXIDE USED IN MRI CONTRAST APPLICATIONS, 2006-2012 ($ MILLIONS)
  • TRANSFECTION REAGENTS
    • Background
    • Materials, Production, and Technical Requirements
    • Commercial and Regulatory Status
    • World Markets
• Table 36 WORLD MARKET PROJECTIONS FOR DENDRIMERS USED IN TRANSFECTON REAGENTS, THROUGH 2012
• Figure 17 PROJECTED TRENDS IN THE WORLD MARKET FOR DENDRIMERS USED IN TRANSFECTION REAGENTS, 2006-2012 ($ MILLIONS)
  • ANTIOXIDANTS
    • Background
    • Materials, Production, and Technical Requirements
    • Commercial and Regulatory Status
  • World Markets
• Table 37 WORLD MARKET PROJECTIONS FOR SILICA HYDRIDE NANOPARTICLES USED IN NUTRACEUTICALS, THROUGH 2012 (KG/$ MILLIONS)
• Figure 18 PROJECTED TRENDS IN THE WORLD MARKET FOR SILICA HYDRIDE NANOPARTICLES USED IN ANTIOXIDANT NUTRACEUTICAL, 2006-2012 ($ MILLIONS)
  • ORTHOPEDIC AND DENTAL APPLICATIONS
    • Background
  • Materials, Production, and Technical Requirements
  • Commercial and Regulatory Status
• Table 38 COMPANIES ACTIVE IN DEVELOPING NANOPARTICLE-BASED BIOACTIVE CERAMICS
  • World Markets
• Table 39WORLD MARKET PROJECTIONS FOR NANOPARTICLE-BASED SYNTHETIC BONE AND TOOTH ENAMELS, THROUGH 2012 (KG/$ MILLIONS)
• Figure 19 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE HYDROXYAPATITE, 2006-2012 ($ MILLIONS)
  • World Markets (Continued)
• SUNSCREENS AND UV-PROTECTIVE COSMETICS
  • Background
• Table 40 SUNSCREEN INORGANIC AND ORGANIC ACTIVE INGREDIENTS
  • Materials, Production, and Technical Requirements
• Table 41 TECHNICAL REQUIREMENTS FOR NANOPARTICLES IN UV-SHIELDING APPLICATIONS
  • Commercial and Regulatory Status
• Table 42 PRODUCERS OF TIO2 AND ZNO PARTICLES AND DISPERSIONS
  • Commercial and Regulatory Status (Continued)
• Table 43 SUNSCREEN AND DAILY-USE SKIN PROTECTION PRODUCTS CONTAINING NANOPARTICULATE TIO2 AND ZNO
  • Recent Developments
    • Process for Preparing Passivated TiO2 Nanoparticles
    • Titanium Dioxide Coated with Silicon Dioxide
    • Coated TiO2 Nanoparticles
  • World Markets
• Table 44 PROJECTED TRENDS IN WORLDWIDE SUNSCREEN SALES, THROUGH 2012 ($ BILLIONS)
• Figure 20 PROJECTED TRENDS IN THE WORLD MARKET FOR TIO2 AND ZNO NANOPARTICLES USED IN SUNCREENS AND OTHER SKIN CARE PRODUCTS, 2006-2012 ($ MILLIONS)
• Table 45 WORLD MARKET PROJECTIONS FOR TIO2 AND ZNO NANOPARTICLES IN SUNSCREEN APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)
• Chapter 6 - COMPANY PROFILES
  • ADVANCED NANOTECHNOLOGY, LTD.
  • AMAG PHARMACEUTICALS, INC.
  • ALTAIR NANOTECHNOLOGIES, INC.
  • ANGSTROM MEDICA, INC.
  • APHIOS CORP.
  • ARGONIDE CORP.
  • BANGS LABORATORIES, INC.
  • BASF AG
  • BERKELEY ADVANCED BIOMATERIALS, INC.
  • BIOPHAN TECHNOLOGIES, INC.
  • CAPSULUTION NANOSCIENCE AG
  • CYTIMMUNE SCIENCES, INC.
  • DENDRITECH, INC.
  • DENDRITIC NANOTECHNOLOGIES, INC.
  • DOW CHEMICAL CO.
  • DONG SEO, INC.
  • DYNAL BIOTECH ASA
  • ELEMENTIS SPECIALTIES
  • EMD CHEMICALS, INC.
  • EVIDENT TECHNOLOGIES
  • EVONIK DEGUSSA GMBH
  • FLAMEL TECHNOLOGIES S.A.
  • INFRAMAT CORP.
  • INVITROGEN CORP.
  • ISHIHARA SANGYO KAISHA, LTD.
  • KEMIRA SPECIALTY
  • MAGNABIOSCIENCES, LLC
  • MICROCOSM, INC.
  • MICROMOD PARTIKELTECHNOLOGIE GMBH
  • NANOCARRIER CORP., LTD.
  • NANOPHASE TECHNOLOGIES CORP.
  • NANOPROBES, INC.
  • NANOSPHERE, INC.
  • NOVAVAX, INC.
  • NUCRYST PHARMACEUTICALS
  • NYMOX PHARMACEUTICAL CORP.
  • ORASURE TECHNOLOGIES, INC.
  • ORTHOVITA, INC.
  • OSI PHARMACEUTICALS, INC.
  • PHARMASOL GMBH
  • POLYSCIENCES, INC.
  • POWDERMED, LTD.
  • QUANTUM DOT CORP.
  • QIAGEN N.V.
  • RBC LIFE SCIENCES, INC.
  • SACHTLEBEN CHEMIE GMBH
  • SHOWA DENKO K.K.
  • SKYEPHARMA, PLC
  • SOMALOGIC, INC.
  • STARPHARMA HOLDINGS, LTD.
  • SURFACINE DEVELOPMENT CO.
  • TAYCA CORP.