The Probiotics Market: Ingredients, Supplements, Foods

SUMMARY

The report:

• Examines the applications for probiotics in supplements and food products
• Looks at recent historical trends in U.S. sales of probiotics
• Details the structure, technologies and relevant government regulatory provisions that govern activities in the industry
• Considers trends in domestic probiotic sales compared to those in Canada, the European Union and Japan
• Includes market forecasts through
• Profiles the major probiotics companies from the U.S., Canada, the European Union and Japan.

INTRODUCTION

STUDY GOALS AND OBJECTIVES

The goal of BCC Research in conducting this study is to present a comprehensive picture of recent trends in the global probiotics industry through 2007, and to develop market projections for the 2008 to 2013 period. The study covers the following principal areas: probiotics as ingredients and probiotic applications for supplements and foods. The report identifies a number of factors that have shaped historical trends in sales revenues and those that are projected to contribute to future trends in the sales of probiotics. The central roles of scientific research, consumer awareness, and government regulatory provisions are presented and discussed in detail.

REASONS FOR DOING THE STUDY

There is considerable interest in probiotics in both the business and science communities. However, the manufacture of probiotics essentially remains a niche market, and commercial applications in the U.S., currently, are primarily for supplements and dairy-based products. Science is discovering new information about existing and new probiotics, and product manufacturers are tapping into new areas of commercial applications for probiotics. BCC Research examines the explanatory factors underlying past performance and identifies areas that potentially are important to future commercial opportunities in the industry. This report presents an informative balance of the scientific and market factors that are critical in the probiotics industry.

INTENDED AUDIENCE

This report presents valuable information relating to one of the fastest growing segments of the global ingredients, dietary supplement, and food industries. It contributed almost $15 billion in sales to the global economy in 2007. This study will be a resource for readers with an interest in the dietary supplement and functional foods industries in general, and in probiotics in particular. Market projections developed in this study provide a context for assessing potential growth through 2013, and suggest areas of business opportunities in the U.S. and in the international probiotics industry. Companies already invested in the industry, and those seeking areas of expansion will find this material useful in their decision-making.

SCOPE OF REPORT

The report represents a complete update of the BCC Research report on the probiotics industry published in 2005. The current report covers the important role of U.S. and foreign manufacturers in the market for probiotics. The study also includes a detailed examination of existing and emerging applications for probiotics in supplements and food products. It describes in detail, recent historical trends in global sales of probiotics, industry structure, technologies, and relevant government regulatory provisions that govern activities in the industry. Current trends in domestic probiotic sales are compared to current sales trends in Canada, the European Union (EU), and Japan. Profiles of major companies in the U.S. and these countries are included in this report.

INFORMATION SOURCES

This study is the result of extensive research covering materials from diverse sources. BCC surveyed numerous scientific and industry publications on probiotics to develop a qualitative and quantitative analytical framework for the findings documented in this report. Communications with various government and industry experts provided supplemental information on various aspects of the study. Data from the investment community was used to complement and validate other third party industry data.

TABLE OF CONTENTS

• The Probiotics Market: Ingredients, Supplements, Foods

Chapter- 1: SUMMARY

• SUMMARY TABLE GLOBAL SALES OF PROBIOTIC INGREDIENTS, SUPPLEMENTS, AND FOODS, THROUGH 2013 ($ MILLIONS)
• SUMMARY FIGURE SHARES OF GLOBAL SALES OF PROBIOTICS, BY TYPE, 2006-2013 (%)

Chapter- 2: OVERVIEW

• BACKGROUND
• INDUSTRY CONCEPTS
• PROBIOTICS AND INTESTINAL HEALTH
• RESIDENT AND TRANSIENT PROBIOTICS
• PROBIOTIC CLASSIFICATION AND LABELING
• PREBIOTICS
• SYNBIOTICS
• PROBIOTIC DELIVERY SYSTEM
• IMPORTANCE OF PROBIOTICS
• FORESEEABLE DEVELOPMENTS
• Foreseeable Developments (Continued)

Chapter- 3: THE GLOBAL PROBIOTIC INGREDIENTS INDUSTRY

• BACKGROUND
• INDUSTRY STRUCTURE
• GLOBAL LEADERS
• Strategic Alliances, Agreements, and Acquisitions
• BioGaia Partners
• BioGaia and Ferring Pharmaceuticals
• BioGaia and Earth Biochemical Co., Ltd.
• BioGaia in South Africa
• BioGaia in South America
• BioGaia in Turkey
• BioGaia in the United States
• Chr. Hansen Alliances and Acquisition
• Chr. Hansen and Valio Ltd.
• Chr. Hansen and Urex Biotech
• Chr. Hansen and Jarrow Formulas
• Chr. Hansen's Acquires Medipharm
• Chr. Hansen and Genome Technology
• Danisco Developments
• Danisco HOWARU Brand Name
• HOWARU-Anyhow you want it
• Danisco and New Probiotic Applications
• Groupe Danone Alliances
• Danone and Yakult
• Danone and Integrated Genomics
• Institut Rosell-Lallemand's Strategy
• Institut Rosell and Research Collaborators
• Institut Rosell Products for Target Markets
• Institut Rosell's Global Marketing Partners
• Nebraska Cultures and Wilke Resources
• The Probi Network
• Probi Research Connections
• Probi and Institut Rosell
• Probi and Health World
• Probi and Metagenics
• Probi and NextFoods
• Probi and Kraft
• Ganeden Biotech-A Significant New Player
• The $12 Million Boost from DSM N.V.
• Ganeden and PLT
• Government Participation
• USDA-ARS
• U.S. Department of Energy-Joint Genome Institute
• Funding Agencies for Probiotic Research in Canada
• PROEUHEALTH
• PROBIOTIC INGREDIENTS BY TYPE
• THE GI TRACT
• Immune System Function
• Bacterial Genera
• PROBIOTICS OF THE LACTOBACILLUS GENUS
• L. acidophilus
  • TABLE 1 PROPRIETARY STRAINS OF L. ACIDOPHILUS, BY PRODUCER
• L. acidophilus DDS-1
• L. acidophilus LA-1 (L. acidophilus LA-5)
• L. acidophilus LAFTI L10
• L. acidophilus LB Rosell-52
• L. acidophilus NCFM
• L. acidophilus SBT-2062, SBT-2071, SBT-2074
• L. bulgaricus
• L. casei
  • TABLE 2 PROPRIETARY STRAINS OF L. CASEI, BY PRODUCER
• L. casei DN114001 and L. casei immunitas
• L. casei LAFTI L26
• L. casei 431-CRL-431
• L. Casei Shirota
• L. helveticus
• L. johnsonii
• L. plantarum
  • TABLE 3 PROPRIETARY STRAINS OF L. PLANTARUM, BY PRODUCER
• L. reuteri
  • TABLE 4 PROPRIETARY STRAINS OF L. REUTERI, BY PRODUCER
• L. rhamnosus
  • TABLE 5 PROPRIETARY STRAINS OF L. RHAMNOSUS, BY PRODUCER
• L. rhamnosus GG (LGG)
• L. rhamnosus GR-1
• L. rhamnosus Rosell-11
• L. salivarius
• PROBIOTICS OF THE BIFIDOBACTERIUM GENUS
• B. bifidum (B. lactis)
  • TABLE 6 PROPRIETARY STRAINS OF B. BIFIDUM, BY PRODUCER
• B. lactis BB-12
• B. LAFTI B94
• B. breve
  • TABLE 7 PROPRIETARY STRAINS OF B. BREVE, BY PRODUCER
• B. infantis
  • TABLE 8 PROPRIETARY STRAINS OF B. INFANTIS, BY PRODUCER
• B. longum
  • TABLE 9 PROPRIETARY STRAINS OF B. LONGUM, BY PRODUCER
• PROBIOTICS OF THE STREPTOCOCCUS GENUS
• S. thermophilus
• OTHER PROBIOTIC BACTERIA
• Bacillus Coagulans (B. coagulans)
• B. coagulans GBI-30, 6086 (GanedenBC30)
• Lactococcus
• Pediococcus
• SELECTION CRITERIA AND SPECIES-SPECIFIC BENEFICIAL PHYSIOLOGICAL EFFECTS OF PROBIOTICS
• Selection Criteria for Probiotics Strains
  • TABLE 10 SELECTION CRITERIA FOR PROBIOTICS
• Science-based Physiological Benefits
  • TABLE 11 HEALTH BENEFITS ASSOCIATED WITH LACTOBACILLUS PROBIOTICS
  • TABLE 11 (CONTINUED)
  • TABLE 12 HEALTH BENEFITS ASSOCIATED WITH BIFIDOBACTERIUM PROBIOTICS
  • TABLE 13 HEALTH BENEFITS ASSOCIATED WITH STREPTOCOCCUS PROBIOTICS
• MECHANISMS OF PROBIOTIC ACTIVITY
  • TABLE 14 PROPOSED MECHANISMS OF PROBIOTIC EFFECT
  • TABLE 14 (CONTINUED)
• SALES OF PROBIOTIC INGREDIENTS BY TYPE
• INDUSTRY DATA
• MARKET DRIVERS
• Better Understanding of Probiotics through Sustained Research
• Research Targeting Health Conditions and Population Segment
• Allergies
• Cardiovascular Disease: High Blood Pressure and High Blood Cholesterol
• Chronic Constipation
• Colorectal Cancer
• Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis
• Vaginal Infections
• Fine-tuning Consumer Education
• The Regulatory Environment
• RECENT TRENDS
• Global Sales of Probiotic Ingredients by Type
• Global Sales of Lactobacillus Probiotic Ingredients
  • FIGURE 1 GLOBAL SALES OF LACTOBACILLUS PROBIOTICS AS A SHARE OF PROBIOTIC INGREDIENT SALES, 2007 (%)
• Global Sales of Bifidobacterium Probiotic Ingredients
  • FIGURE 2 GLOBAL SALES OF BIFIDOBACTERIUM PROBIOTICS AS A SHARE OF PROBIOTIC INGREDIENT SALES, 2007 (%)
• Global Sales of Streptococcus Probiotic Ingredients
  • FIGURE 3 GLOBAL SALES OF STREPTOCOCCUS PROBIOTICS AS A SHARE OF PROBIOTIC INGREDIENT SALES, 2007 (%)
• Total Global Sales of Probiotic Ingredients by Type
  • TABLE 15 ESTIMATED GLOBAL SALES AND MARKET SHARES OF PROBIOTIC INGREDIENT MANUFACTURERS, 2007
• Total Global Sales of Probiotic Ingredients by Region
  • TABLE 16 ESTIMATED GLOBAL SALES OF PROBIOTIC INGREDIENTS BY REGION, 2007
• MAJOR MANUFACTURERS OF PROBIOTIC INGREDIENTS
  • TABLE 17 MAJOR MANUFACTURERS OF PROBIOTIC INGREDIENTS
• SALE PROJECTIONS AND MARKET SIZE
• Sale Projections and Market Size (Continued)
  • TABLE 18 GLOBAL SALES OF PROBIOTIC INGREDIENTS BY TYPE, THROUGH 2013 ($ MILLIONS)
  • FIGURE 4 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC INGREDIENTS, BY TYPE, 2007 AND 2013 (%)
  • TABLE 19 GLOBAL SALES OF PROBIOTIC INGREDIENTS BY REGION, THROUGH 2013 ($ MILLIONS)
  • FIGURE 5 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC INGREDIENTS, BY REGION, 2007 AND 2013 (%)
  • FIGURE 5 (CONTINUED)

Chapter- 4: THE GLOBAL PROBIOTIC SUPPLEMENTS INDUSTRY

• BACKGROUND
• INDUSTRY STRUCTURE
• MARKET SHARE BASED ON ACCESS TO PROPRIETARY INGREDIENTS
• Full In-house Processing
• Bulk Ingredient Suppliers
• Contract Manufacturing
• Licensing Agreements
• MARKET SHARE BASED ON OWNERSHIP OF PROCESSING TECHNOLOGIES
  • TABLE 20 OWNERSHIP OF PROCESSING TECHNOLOGIES
• Bio-tract
• LiveBac
• Poten-Zyme (also written as potenzyme)
• Probiocap
• Probio-Tec
• STAR Technology
• True Delivery Technology
• MAKTrek ByPass
• Triple-shell Technology
• Viablend
• MARKET SHARES BASED ON PRODUCT DIFFERENTIATION
• Product Differentiation Based on Brand Name
  • TABLE 21 SAMPLE OF PROBIOTIC SUPPLEMENT BRANDS
• Product Differentiation Based on Formulations
• Single-species Probiotic Supplement Products
  • TABLE 22 COMPOSITION OF SINGLE-SPECIES PROBIOTIC SUPPLEMENTS FOR ADULTS
• Single-species Supplement from Bio-Energy Systems
• Single-species Supplement from Amerifit Nutrition
• Single-species Supplement form Ganeden Biotech
• Single-species Supplement from Jarrow Formulas
• Natren Single-species Supplement
• Single-species Supplement from Nebraska Cultures
• Single-species Supplement from NOW Foods
• Single-species Supplement from Solgar
• Multi-species Probiotic Supplement Products
• Multi-species Probiotic Supplement Products (continued)
• Multi-species Probiotic Supplement Products for Adults
• Multi-species Adult Probiotic Supplement from American Biologics
  • TABLE 23 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM AMERICAN BIOLOGICS
• Multi-species Adult Probiotic Supplement from Jarrow Formulas
  • TABLE 24 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM JARROW FORMULAS
• Multi-species Adult Probiotic Supplement from Kirkman Laboratories
  • TABLE 25 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM KIRKMAN LABORATORIES
• Multispecies Adult Probiotic Supplement from Natren
  • TABLE 26 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM NATREN
• Multi-species Adult Probiotic Supplement from NOW Foods
  • TABLE 27 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM NOW FOODS
• Multispecies Adult Probiotic Supplement from Solaray
  • TABLE 28 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM SOLARAY
• Multispecies Probiotic Supplement Lozenge from Udo's Choice
  • TABLE 29 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM UDO'S CHOICE
• Multi-species Probiotic Supplement Products for Infants and Children
• Multi-species Probiotic Supplement for Infants and Children from American Biologics
  • TABLE 30 MULTI-SPECIES PROBIOTIC SUPPLEMENTS FOR INFANTS AND CHILDREN FROM AMERICAN BIOLOGICS
• Multispecies Probiotic Supplement for Infants and Children from Country Life
  • TABLE 31 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR INFANTS AND CHILDREN FROM COUNTRY LIFE
• Multispecies Probiotic Supplement for Infants and Children from Jarrow Formulas
  • TABLE 32 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR INFANTS AND CHILDREN FROM JARROW FORMULAS
• Multispecies Probiotic Supplement for Infants and Children from Nature's Plus
  • TABLE 33 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR INFANTS AND CHILDREN FROM NATURE'S PLUS
• Multi-species Probiotic Supplement for Infants and Children from Udo's Choice
  • TABLE 34 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR CHILDREN FROM UDO'S CHOICE
• Product Differentiation Based on Probiotic Dosage
• PROBIOTIC SUPPLEMENTS FOR ANIMAL USE
• Market Potential for Animal Probiotic Supplements
• Market Potential for Animal Probiotic Supplements (Continued)
  • TABLE 35 U.S. PET OWNERSHIP, BY TYPE, 2007
• Samples of Probiotic Supplements for Animals
  • TABLE 36 PROBIOTIC SUPPLEMENTS FOR ANIMAL USE
• Multi-species Probiotic Supplement for Pets from Jarrow Formulas
  • TABLE 37 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR PETS FROM JARROW FORMULAS
• Multi-species Probiotic Supplement from Natur's Way
  • TABLE 38 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR PETS FROM NATURE'S WAY
• DISTRIBUTION CHANNELS FOR PROBIOTIC SUPPLEMENTS
• The Internet as a Distribution Channel
• SALES OF PROBIOTIC SUPPLEMENTS BY TYPE OF FORMULATION
• INDUSTRY DATA
• MARKET DRIVERS
• Science-based Substantiation of Beneficial Claims
• Continuing Consumer Education
• Demographics
• Continuing Improvement in Processing Technologies
• Expanding the Market Base-Animal Supplements
• Product Innovations
• Carving a Niche
• New Product Format
• BioGaia's Drops, Lozenges, and Straws
• Ganeden's Topical applications
• New application frontier-Cosmetics
• Natren's Probiotic Cosmetics
• Regulatory Changes and Industry Reform
• RECENT SALES TRENDS
• Global Sales of Probiotic Supplements by Type
• Global Sales of Probiotic Supplements in Capsule Form
  • FIGURE 6 GLOBAL SALES OF PROBIOTIC CAPSULES AS A SHARE OF PROBIOTIC SUPPLEMENT SALES, 2007 (%)
• Global Sales of Probiotic Supplements in Tablet Form
  • FIGURE 7 GLOBAL SALES OF PROBIOTIC TABLETS AS A SHARE OF PROBIOTIC SUPPLEMENT SALES, 2007 (%)
• Global Sales of Probiotic Supplements in Powder Form
  • FIGURE 8 GLOBAL SALES OF PROBIOTIC POWDER AS A SHARE OF PROBIOTIC SUPPLEMENT SALES, 2007 (%)
• Total Global Sales of Probiotic Supplements by Type
  • TABLE 39 ESTIMATED GLOBAL SALES AND MARKET SHARES OF PROBIOTIC SUPPLEMENT MANUFACTURERS, 2007
• MAJOR PROBIOTIC SUPPLEMENT MANUFACTURERS
  • TABLE 40 MAJOR MANUFACTURERS OF PROBIOTIC SUPPLEMENTS
  • TABLE 40 (CONTINUED)
• SALE PROJECTIONS AND MARKET SIZE
• Sale Projections and Market Size (Continued)
  • TABLE 41 GLOBAL SALES OF PROBIOTIC SUPPLEMENTS BY TYPE, THROUGH 2013 ($ MILLIONS)
  • FIGURE 9 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC SUPPLEMENTS, BY TYPE, 2007 AND 2013 (%)
  • FIGURE 9 (CONTINUED)
  • FIGURE 10 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC SUPPLEMENTS, BY REGION, 2007 AND 2013 (%)

Chapter- 5: THE GLOBAL PROBIOTIC FOODS INDUSTRY

• BACKGROUND
• INDUSTRY STRUCTURE
• INDUSTRY DYNAMICS
• Structural Changes in Dairy Farming
• Structural Changes in Dairy Processing
• Stonyfield Farm Connections
• Stonyfield Farm and Brown Cow
• The Danone Groupe Partnership
• Strategic Ingredient Sourcing from BioGaia
• International Sister Companies
• Lifeway Foods Extends its Reach
• The Acquisition of Helios Nutrition
• Entry into Foodservice Market
• New Sales Concept
• Growing the Niche
• Private Labels and Contract Manufacturing
• PROBIOTIC FOODS BY TYPE
• STARTER CULTURE
  • TABLE 43 BRANDED COMMERCIAL STARTER CULTURES, BY PRODUCER AND APPLICATION
• DAIRY-BASED PROBIOTIC FOOD PRODUCTS BY TYPE
• Yogurt
• Natural-set Yogurt
• Stirred Yogurt
• Drinkable Yogurt
• The Probiotic Content of Yogurt
• The Probiotic Content ... (Continued)
  • TABLE 44 PROBIOTIC COMPOSITION OF SELECT YOGURT BRANDS
• Kefir
• Kefir (Continued)
  • TABLE 45 PROBIOTIC COMPOSITION OF SELECT KEFIR BRANDS
• Dairy-based Cultured Probiotic Drinks
  • TABLE 46 PROBIOTIC COMPOSITION OF SELECT CULTURED PROBIOTIC DRINKS
• Non-dairy Based Cultured Drinks
  • TABLE 47 PROBIOTIC COMPOSITION OF SOY-BASED PROBIOTIC YOGURT
• RECENT AND EMERGING COMMERCIALLY SIGNIFICANT PROBIOTIC FOODS
• Probiotic Cheese Products
• Butler's Probiotic Delicious Creamy Handmade Cheese
  • TABLE 48 PROBIOTIC CHEESE, BY MANUFACTURER
• Probiotic Infant Formula in the U.S. Market
• Probiotic Ice Cream and Iced Lollies
• Probiotic Breakfast and Snack Foods
  • TABLE 49 SAMPLE OF PROBIOTIC BREAKFAST AND SNACK BARS
• Probiotic Drinks and Juices
  • TABLE 50 SAMPLE OF PROBIOTIC DRINKS AND JUICES
• SALES OF PROBIOTIC FOODS BY TYPE
• INDUSTRY DATA
• MARKET DRIVERS
• Untapped Market Potential
• Consumer Preferences
• Emerging Probiotic Foods
• Food Processing Challenge
• RECENT TRENDS IN PROBIOTIC FOOD SALES
• Global Sales of Probiotic Foods by Type
• Global Sales of Probiotic Yogurt
  • FIGURE 11 GLOBAL SALES OF PROBIOTIC YOGURT AS A SHARE OF PROBIOTIC FOODS, 2007 (%)
• Global Sales of Probiotic Kefir
  • FIGURE 12 GLOBAL SALES OF PROBIOTIC KEFIR, AS A SHARE OF PROBIOTIC FOODS, 2007 (%)
• Global Sales of Probiotic Cultured Drinks
  • FIGURE 13 GLOBAL SALES OF PROBIOTIC CULTURED DRINKS AS A SHARE OF PROBIOTIC FOODS, 2007 (%)
• Global Sales of Probiotic Cheese Products
  • FIGURE 14 GLOBAL SALES OF PROBIOTIC CHEESE PRODUCTS AS A SHARE OF PROBIOTIC FOODS, 2007 (%)
• Total Global Sales of Probiotic Foods by Type
  • TABLE 51 ESTIMATED GLOBAL SALES AND MARKET SHARES OF PROBIOTIC FOOD MANUFACTURERS, 2007
• Total Global Sales of Probiotic Foods by Region
  • TABLE 52 ESTIMATED GLOBAL SALES OF PROBIOTIC FOODS BY REGION, 2007
• MAJOR MANUFACTURERS OF PROBIOTIC FOODS
  • TABLE 53 MAJOR PROBIOTIC FOOD MANUFACTURERS
• SALE PROJECTIONS AND MARKET SIZE
  • TABLE 54 GLOBAL SALES OF PROBIOTIC FOODS, BY TYPE, THROUGH 2013 ($ MILLIONS)
  • FIGURE 15 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC FOODS, BY TYPE, 2007 AND 2013 (%)
  • TABLE 55 GLOBAL SALES OF PROBIOTIC FOODS, BY REGION, THROUGH 2013 ($ MILLIONS)
  • FIGURE 16 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC FOODS, BY REGION, 2007 AND 2013 (%)

Chapter- 6: REGULATORY GUIDELINES FOR THE PROBIOTICS INDUSTRY

• REGULATORY GUIDELINES FOR THE PROBIOTICS INDUSTRY
• BACKGROUND
• THE CODEX ALIMENTARIUS
• A BRIEF HISTORY OF THE CODEX: THE JOINT FAO-WHO FOOD PROGRAM
• CODEX GUIDELINES FOR THE EVALUATION OF PROBIOTICS
• Genus-Species-Strain
• Screening of Potential Probiotics
• Probiotic Safety Considerations
• Probiotic Health Claims
• Probiotic Product Labeling
• Codex Guidelines on Nutrition Claims
• Codex Standard for Food Additives
• CODEX STANDARD FOR GOOD MANUFACTURING PRACTICE (GMP)
• CODEX STANDARD FOR FERMENTED MILK PRODUCTS
  • TABLE 56 CODEX STANDARDS FOR FERMENTED MILK PRODUCTS
• U.S. REGULATORY PROVISIONS
• REGULATIONS RELATING TO INGREDIENTS
• Legal Definition of Ingredient Products
• Definition of a Food Additive
• GRAS Provisions
• The Food Additive Petition Process
• Premarket Review Provision for New Dietary Ingredient
• REGULATIONS RELATING TO DIETARY SUPPLEMENTS
• Legal Definition of a Supplement Product
• Approved Product Claims for Dietary Supplements
• Supplement Product Health Claims
• The Nutrition Labeling and Education Act (NLEA) of 1990
• The Food and Drug Administration Modernization Act (FDAMA) of 1997
• Qualified Health Claims
• Product Nutrient Content Claims
• Structural-Function Claims for Supplement Products
• Recent and Foreseeable Developments in the U.S. Regulatory Process
• Scientific Evaluation of Health Claims
• Changes in Manufacturing Practices
• Guidance Relating to Complementary and Alternative Medicine Products
• REGULATORY PROVISIONS RELATING TO FOOD PRODUCTS
• Legal Requirements for Yogurt Products
  • TABLE 57 YOGURT CLASSIFICATION
• GRAS Status of Probiotic Food Ingredients
• Approved Food Product Claims
• Probiotic Food Labeling Gaps
• General Health Claims
• Probiotic Content Information
• Nutrient Content Claims
• CANADIAN REGULATORY PROVISIONS
• HEALTH CANADA OVERSIGHT
• Canada's Natural Health Products Regulations
• Definition of a Natural Health Product
• Regulations Relating to Product Manufacturing
• Licensing Requirement
• Good Manufacturing Practices (GMPs)
• Additional Requirements for Probiotics
• Characterization of Probiotics
• Probiotic Efficacy Considerations
• Probiotic Safety Considerations and Banned Probiotic Strains
• Compliance Policy
• EU REGULATORY PROVISIONS
• A SNAPSHOT OF THE EU
• PRODUCT HEALTH CLAIMS
• Coverage of the Regulation
• General Conditions for Claims
• Scientific Substantiation of Claims
• Restrictions on the Use of Certain Health Claims
• Compliance Deadline
• Transitional and Safeguard Provisions
• REGULATORY PROVISIONS IN JAPAN
• MINISTRY OF HEALTH, LABOR, AND WELFARE OVERSIGHT
• FOOD WITH HEALTH CLAIMS
• Food with Nutrient Function Claims (FNFC)
• Food for Specified Health Uses (FOSHU)
  • TABLE 58 HEALTH CLAIMS UNDER FOSHU
• Requirements for FOSHU Approval
• FOODS FOR SPECIAL DIETARY USES (FOSDU)
• Requirements for FOSDU Labeling
• PROHIBITION OF EXAGGERATED AND MISLEADING CLAIMS
• THE ROLE OF EXPERT GROUPS AND PROFESSIONAL ASSOCIATIONS
• The International Scientific Association for Probiotics and Prebiotics (ISAPP)
• The ISAPP Industry Advisory Committee
• Recommended Industry Standards
• The European Food & Feed Cultures Association (EFFCA)
• The International Probiotics Association (IPA)
• The IPA Seal of Quality
• The U.S. Institute of Medicine (IOM)
• The U.S. National Yogurt Association (NYA)
• NYA Seal
• NYA Probiotic Council
• The American Dietetic Association (ADA)
• The U.S. Council for Responsible Nutrition (CRN)
• Role of Consumer Watchdog Groups
• The Council for Agricultural Science and Technology (CAST)
• ConsumerLab.com

Chapter- 7: TECHNOLOGY AND PATENT ANALYSIS

• BACKGROUND
• CURRENT PROCESSING TECHNOLOGIES
• FERMENTATION
• Lactic Acid Fermentation
• Batch Fermentation
• Limitations of the Fermentation Process
• CENTRIFUGATION
• Differential Centrifugation
• ULTRAFILTRATION
• Nanofiltration
• LYOPHILIZATION (FREEZE-DRYING)
• Lyophilizer
• ENCAPSULATION AND TABLETING
• Spray-drying Encapsulation Technologies
• Tableting
• Emerging Encapsulation Technologies
• Cell Biotech and Dual-coating
• EnCoate and Bioshield
• Riddet Centre and Biopolymers
• New Coating Materials
• PATENT ANALYSIS
• PATENTS RELATING TO EXISTING AND NEW PROBIOTIC STRAINS
  • TABLE 59 U.S. PATENT AWARDS FOR PROBIOTIC SPECIES, BY TYPE, 2006-2007
  • TABLE 60 U.S. PATENT AWARDS FOR PROBIOTIC SPECIES BY REGION, 2006-2007
• Sample of Patents for Existing Probiotics
• Lactic Acid Bacteria for the Treatment and or Prophylaxis of Giardiasis
• Lactobacillus Reuteri Useful as Probiotics
• Enzyme Isolated from a Bifidobacterium
• Sample of Patents for New Probiotic Strains
• Lactic Acid Producing Bacteria for use as a Probiotic in the Human Vagina
• Strain of Microorganism Lactobacillus Fermentum ME-3 as Novel Anti-microbial and Anti-oxidative Probiotic
• Microorganism Pediococcus Pentosaceus EROM101, Having Immune Enhancement, Anti-cancer, and Antimicrobial Activities
• Strain of Lactic Acid Bacterium and Edible Compositions, Drugs and Veterinary Products Containing It
• NCC2705-The Genome of a Bifidobacterium
• Lactobacilli Expressing Biologically Active Polypeptides and Uses Thereof
• Composition Comprising a Lactobacillus Pentosus Strain and Uses Thereof
• PATENTS RELATING TO PROBIOTIC APPLICATIONS
  • TABLE 61 U.S. PATENT AWARDS FOR PROBIOTIC APPLICATIONS BY TYPE, 2006-2007
• Sample of Patents for Probiotic Starter Culture
• Compositions and methods for producing fermentation products and residuals
• Lactobacillus stains and use thereof in fermentation for L-lactic acid production
• Fragment of L. Lactis Plasmid Conferring Anti-phage Activity and Uses Thereof
• Sample of Patents for Probiotic Fermented Products
• Ferment Activator Based on Lactic Acid Bacteria and Method for Preparing a Dairy Product Using Same
• Method for Producing Fermented Milk Product
• Powder for Preparation of a Probiotic Yogurt Food
• Sample of Patents for Probiotic Therapeutic Products
• Method for Preventing or Treating the Development of Respiratory Allergies
• Kit with Enteral Dietary Composition Consisting of Streptococcus Thermophilus, Bifidobacterium Infantis, and Bifidobacterium Longum
• Bifidobacterium in the Treatment of Inflammatory Disease
• Selection and Uses of Lactic Bacteria Strains Modulating Non-specific Immunity
• Lactic Acid Bacteria-containing Probiotics Products
• Selection and Use of Lactic Acid Bacteria for Reducing Inflammation Caused By Helicobacter
• Lactobacillus paracasei subsp. Paracasei strain antibacterial against H. Pylori and E. coli
• Microorganism Strain of GM-020 of Lactobacillus Rhamnosus and its Use for Treating Obesity
• PATENTS RELATING TO PROBIOTIC PROCESSING TECHNOLOGIES
  • TABLE 62 U.S. PATENTS FOR SELECT PROCESSING TECHNOLOGIES BY TYPE, 2006-2007
• Lyophilization of Human Platelets
• Formulations to Increase In Vivo Survival of Probiotic Bacteria and Extend Their Shelf life
• Prebiotic and Preservative Uses of Oil-emulsified Probiotic Encapsulations
• Encapsulation of Sensitive Liquid Components Into a Matrix to Obtain Discrete Shelf-stable Particles
• Tablets Containing Heat Sensitive Materials and Method for Forming Thereof
• Tablets Comprising Microorganisms and Method for Preparation of the Tablets

Chapter- 8: COMPANY PROFILES

• BACKGROUND
• GLOBAL MANUFACTURERS OF PROBIOTIC INGREDIENTS
• BIO-ENERGY SYSTEMS, INC.
• BIOGAIA
• CHR. HANSEN A-S
• CHR. HANSEN, INC.
• DANISCO CULTURES A-S
• GROUPE DANONE
• THE DANNON CO., INC.
• ROYAL DSM N.V. (DSM FOOD SPECIALTIES)
• INSTITUT ROSELL-LALLEMAND
• MORINAGA MILK INDUSTRY
• NEBRASKA CULTURES
• NESTLE USA, INC.
• PROBI AB
• SNOW BRAND MILK PRODUCTS
• UREX BIOTECH, INC.
• YAKULT HONSHA COMPANY, LTD.
• MAJOR MANUFACTURERS OF PROBIOTIC SUPPLEMENTS
• AMERICAN BIOLOGICS
• AMERIFIT NUTRITION INC.
• BIO-K+ INTERNATIONAL INC.
• COUNTRY LIFE VITAMINS
• ENZYMATIC THERAPY
• GANEDEN BIOTECH
• GARDEN OF LIFE, INC.
• JARROW FORMULAS
• KIRKMAN LABORATORIES
• NATREN
• NATROL, INC.
• NATURE'S PLUS-NATURAL ORGANICS, INC.
• NATURE'S WAY
• NOW FOODS
• NUTRACEUTICAL CORP.
• NUTRACEUTIX, INC.
• SOLGAR VITAMIN & HERB CO.
• UAS LABORATORIES
• MAJOR PROBIOTIC FOOD MANUFACTURERS
• ARLA FOODS
• CASCADE FRESH
• CAMPINA
• DAIRY FARMERS OF AMERICA, INC.
• DAIRY CREST GROUP, PLC
• FONTERRA COOPERATIVE GROUP
• FROMAGERIES BEL
• GENERAL MILLS
• HP HOOD, LLC
• JOHANNA FOODS, INC.
• KRAFT FOODS
• LIFEWAY FOODS
• MEIJI DAIRIES CORPORATION
• OLD HOME FOODS, INC.
• PARMALAT S.P.A
• SPRINGFIELD CREAMERY, INC.
• STONYFIELD FARM
• TILLAMOOK COUNTY CREAMERY ASSOCIATION
• UNILEVER
• VALIO GROUP
• WALLABY YOGURT CO.
• WELLS' DAIRY, INC.
• WIMM-BILL-DANN FOODS