| Request a sample from "The Infoshop", another service of Global Information.
|
SUMMARY
Executive Summary
The commercial and therapeutic success of antibodies like Rituxan, Avastin,
and Erbitux will force the industry to look into the next generation of
therapeutic antibodies, preparing themselves for the second wave in the
lucrative field of therapeutic antibodies. Today, there are more than 190
companies plus partners developing more than 430 antibody based oncology drugs
in more than 770 developmental projects. In all targeting around 50 different
cancer indications. The number of antibody targets has increased to over 170
described molecular targets in just a few years. These targets are further
categorized on the CD-ROM by 37 classifications of molecular function and with
pathway referals to BioCarta, KEGG and NetPath. Read more below on how the
Antibody in Oncology: Drug Pipeline Update is organized.
How May Drug Pipeline Update Be of Use?
- Show investors/board/management that you are right on top of drug
development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc.
- Jump start competitive drug intelligence operations
- Excellent starting point for world wide benchmarking
- Compare portfolio and therapy focus with your peers
- Speed up pro-active in-/out licensing strategy work
- Fast and easy way of tracking drugs using search engines; just one click
from inside the application and you may search the World Wide Web and PubMed
for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which
requires no installation on your computer. Please read more about application
features and system requirements below.
Drug Pipeline Update at a Glance
- Investigators
- Includes more than 190 principal investigators plus their collaborators.
There is direct access from inside the application to web pages of all
principal investigators.
- Note: You are able to sort and find drugs according to investigators and
partners from drop-down menus in the application. You may also sort and find
drugs according to country of investigator.
- Drug name & Synonyms
- Lists commercial, generic and code names for drugs. In all more than 700
names
- Developmental stage
- This Drug Pipeline Update contains more than 430 antibody drugs in
active development and more than 770 developmental projects:
- 13 marketed drugs
- > 45 projects in Phase III
- > 170 projects in Phase II
- > 150 projects in Phase I
- > 370 projects in Preclinical
- Note: You are able to sort and find drugs according to developmental
stage from drop-down menu in the application.
- Indications
- Included antibody drugs are in development for over 95 indications,
where of 50+ are different cancer indications. All antibodies are in
development for the treatment of cancer.
- Note: You are able to sort and find drugs according to type of
indication from drop-down menu in the application.
- Targets
- Identified drugs are linked to more than 170 different targets,
divided into 37 classifications of molecular function:
- - Auxiliary transport protein activity
- - Carboxypeptidase activity
- - Catalytic activity
- - Cell adhesion molecule activity
- - Chaperone activity
- - Chemokine activity
- - Cofactor binding
- - Complement activity
- - Cytokine activity
- - DNA topoisomerase activity
- - Extracellular matrix structural constituent
- - G-protein coupled receptor activity
- - Growth factor activity
- - Hormone activity
- - Hydrolase activity
- - Intracellular ligand-gated ion channel activity
- - Metallopeptidase activity
- - MHC class I receptor activity
- - Molecular function unknown
- - Oxidoreductase activity
- - Peptidase activity
- - Peptide hormone
- - Protease inhibitor activity
- - Protein binding
- - Protein serine/threonine kinase activity
- - Receptor activity
- - Receptor binding
- - Receptor signaling complex scaffold activity
- - Receptor signaling protein tyrosine phosphatase activity
- - RNA-directed DNA polymerase activity
- - Serine-type peptidase activity
- - T cell receptor activity
- - Translation regulator activity
- - Transmembrane receptor activity
- - Transmembrane receptor protein tyrosine kinase activity
- - Transporter activity
- - Unclassified
- Identified targets are categorized into 18 different primary and
alternate sub-cellular localizations:
- - Centrosome
- - Clathrin-coated vesicle
- - Cytoplasm
- - Cytoplasmic vesicle
- - Cytoskeleton
- - Endoplasmic reticulum
- - Endosome
- - Extracellular
- - Extracellular matrix
- - Golgi apparatus
- - Integral to membrane
- - Lysosome
- - Mitochondrion
- - Nucleolus
- - Nucleus
- - Perinuclear vesicle
- - Plasma membrane
- - Secretory granule
- Note: You are able to sort and find drugs according to target gene name,
molecular function of target, and target localization from drop-down menus
in the application.
- Target Expression Profile
- Direct links are provided from inside the application to 90 protein
expression profiles of 75 drug targets in various human tissues and cancer
types, cell lines and primary cells, including up to:
- - 48 different normal tissue types
- - 20 different types of cancer
- - 47 cell lines
- - 12 samples of primary blood cells
- Pathway Referals
- Identified targets have been cross referenced against their invovlement
in different cellular pathways, according to BioCarta, KEGG and NetPath.
- - BioCarta 128 Pathways
- - KEGG 46 Pathways
- - NetPath 13 Signaling Pathways
- Note: You are able to sort and find drugs according to targeted pathways
from drop-down menues in the application.
- Mechanism
- In total there are at least 180 different drug mechanism of action
represented in this Drug Pipeline Update.
- Note: You are able to sort and find drugs according to mechanism of
action from drop-down menu in the application.
- Compound
- Drug Profile
- Progress analysis and review of drug development. A typical drug profile
reports on, depending on stage of development and available information:
- Drug Name & Synonyms
- Presentation of drug name and synonyms
- Principal Investigator & Partners
- Presentation of principal investigator and partners
- Target and Molecular Function of Target
- Described target(s) is/are presented with:
- Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] -
Molecular Function
- Target Localization
- Described target(s) is/are presented with primary and alternate
localizations.
- Target Expression Profiles
- Links to protein expression profile(s) of target(s) in various human
tissues, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
- Targeted Pathways
- Described target(s) is/are matched for the involvement in cellular
pathways according to BioCarta, KEGG, and NetPath.
- Mechanism
- Developmental Projects
- Summary field of developmental projects for the drug, including
indication, developmental stage and status.
- Example:
- Cancer, myeloma - Phase II Clinical Trial - Active
- Cancer, prostate - Phase III Clinical Trial - Ceased
- Drug Description
- Short introduction to drug
- Compound Data
- Compound type, Chemical name, CAS Number and molecular weight
- Patent Data
- Available patent information related to the drug is presented here.
- Business & Markets
- Collaborations and deals
- Approvals and submissions
- Analyst comments
- Phase III Data
- Available Phase III development data, developmental history and
scientific data.
- Phase II Data
- Available Phase II development data, developmental history and
scientific data.
- Phase I Data
- Available Phase I development data, developmental history and
scientific data.
- Preclinical Data
- Available preclinical development data, developmental history and
scientific data.
- Licensing Information
- Availability for licensing
- Application Features
- Use 13 different parameters, available in drop-down menus, to find
and sort among drugs
- - Drug status
- - Clinical Trial Status
- - Principle Investigator
- - Partners
- - Indication
- - Developmental Stage
- - Compound Type
- - Mechanism
- - Target
- - Molecular Function of Target
- - Target Localization
- - Targeted Pathways
- - Free text search of entire drug profile contents
- Direct linkage from inside the application to related internet
resources
- - Drug data is linked to search engines like Google and PubMed
- - Drug target data is linked directly to BioCarta, Human Protein
Atlas, KEGG, and NetPath
- - Direct links to company web pages of principal investigators
- Export and sharing of information
- - Found information is easily shared with others over e-mail, file
export (xls) or in print
- System Requirements - AMD-Athlon/Pentium II PC
- - Windows 98/NT4/2000/ME/XP/VISTA
- - 8x-speed CD Rom drive
- - SVGA 16 bit display. (32 bit recommended)
- - 32 MB of available RAM (128 MB recommended)
- - Internet access (for related internet resources)
|
