BIOSENSORS IN MEDICAL DIAGNOSTICS

TABLE OF CONTENTS

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

II. EXECUTIVE SUMMARY

1.Global Market Overview and AnalysisII-1

• Commercialization of Biosensors-Challenges AheadII-1
• Facts and General TrendsII-1
• Impediments to CommercializationII-1
• Global Biosensors MarketII-2
• Medical Biosensors: A Promising AreaII-3
• Increasing Medical Applications for BiosensorsII-3
• Painless Technologies Spark Evolution in GlucoseMonitoring SegmentII-3
• Biosensors Primarily Used in Blood Gas/Electrolyte Analyzers, Glucose Meters & Metabolite AnalyzersII-3

2.A RetrospectiveII-4

3.Competitive ScenarioII-5

• Intensity of CompetitionII-5

4.Product OverviewII-7

• About BiosensorsII-7
• Types of BiosensorsII-7
• Components of BiosensorsII-8
• Types of BiosensorsII-8
• Glucose SensorII-8
• Medical TelesensorsII-9
• Detecting Cancer and Health AbnormalitiesII-9
• Lactate SensorII-9
• Alcohol SensorII-10
• Biochemical Oxygen Demand Sensor (BOD)II-10
• BioreportersII-10
• Miniaturized DevicesII-10
• Components of BiosensorsII-10
• Components IncludeII-10
• ReceptorII-10
• TransducerII-10
• SeparatorII-11
• Biological ComponentsII-11
• Attributes of a Good BiosensorII-11
• Classes of BiosensorsII-12
• PotentiometricII-12
• AmperometricII-12
• Optical BiosensorsII-12
• Other Physicochemical BiosensorsII-12
• Methods to Manufacture Optical BiosensorsII-13
• Simple Fiber Optic BiosensorsII-13
• Evanescent Wave SystemII-13
• Surface Plasmon Resonance (SPR)II-13

5.Application AreasII-14

• A. Medical ApplicationsII-14
• Glucose MetersII-14
• The Diabetes Monitoring MarketII-14
• CategorizationII-15
• Biosensors in Home Glucose MonitorsII-15
• PBGM Devices: Based on Photometric or Biosensor TechnologyII-15
• Product Innovations Rule the RoostII-16
• Non-Invasive ProductsII-16
• The Blood Gas MarketII-16
• Sensors Facilitate Analysis of BloodII-17
• Market for DNA Biosensors and Genechips in Nascent StageII-17
• B. Environmental BiosensorsII-18
• C. Industrial ApplicationsII-19
• Summarization of Available Biosensors & Technological ApplicationsII-19
• D. Other Application AreasII-20
• Biological Warfare- An Increasingly Important Area for BiosensorsII-20
• Fingerprinting- A Much Needed Advantage?II-20

6.Recent Industry ActivityII-21

• Cygnus Turns to LiquidationII-21
• TGC Research Acquires Certain Assets of DiametricsII-21
• Diametrics RestructuresII-21
• Abbott Acquires I-StatII-21
• Abbott Laboratories to Acquire TheraSenseII-21
• Seahawk Contracts with In-Q-TelII-22
• Pinnacle Signs an Agreement with PrimetechII-22
• RoboDesign Enters into an Agreement with IsisII-22
• Theron Enters into a Licensing AgreementII-22
• Innovative Biosensors Enters Licensing Agreement with MITII-22
• Biosensors International and X-Cell Medical Mutually Agree to Form a New Company...II-23
• Biosensors International Private Ltd. Divests Stent System to Guidant CorporationII-23
• Medtronic Acquires MiniMed, Inc. and Medical Research Group, Inc.II-23
• Virtek Vision Acquires FONA DiagnosticsII-23
• Dow Corning Strategically Alliances with GenencorII-23
• Synthetic Blood International Obtains PatentII-24
• Physiometrix Inc. Enters into Strategic Alliance with Baxter Health Care CorporationII-24
• Prolinx Forges an Agreement with Texas InstrumentsII-24
• Kumetrix Bags SBIR Contract from NIDDKII-25
• Standard MEMS Forms BioMEMS Technology GroupII-25

7.Technological DevelopmentsII-26

• Innovative Product Launches... On the Way to Hit the MarketII-26
• Molecular Biology- Increasingly Used in the Biosensor BusinessII-26
• Micro-System Platforms for Biosensor ApplicationsII-26
• Microelectromechanical Systems- Creating New HorizonsII-26
• Biochips: Increasingly Being Used in Point-Of-Care DevicesII-27
• Implantable Biosensors: A Possibility in the Near FutureII-27
• Biosensors to Carry Out Medical-Checkups at HomeII-28
• Immunosensors to Enhance Current Immunoassay TechniquesII-28
• Microfluidic Glucose SensorII-28
• Biosensors in Mycotoxin DetectionII-28
• Some Major Technological Developments in Recent YearsII-28
• Animas into Development of Implantable Sensors for Blood GlucoseII-28
• Cytoplex Develops BiosensorII-29
• Immunosensor Ricin DetectorII-29
• KEPCO Develops World's First Heavy Metal Detection BiosensorII-29
• A Novel Approach of Dehydrogenase BiosensorsII-30
• Biosensor to Identify Viruses ElectronicallyII-30
• Electrochemical Array Biosensor TechnologyII-30
• Polymer-Coated Microheaters Enters MarketII-30
• Animas into Development of Implantable Sensors for Blood GlucoseII-30
• Technology Archive ReviewII-30
• UCSD Instrumental in the Development of Polymer-based, Nanoscale BiosensorsII-30
• Applied Digital Solutions, Inc. Launches VeriChip™...II-31
• Applied Digital Solutions, Inc. Incorporates Biosensors Technology in New DeviceII-31
• University of Rhode Island Develops Biosensor to Detect Pathological Bacteria in FoodsII-31
• Cellomics Launches the Development of Biowarfare DetectionII-31
• Biosensors- Speed Pathogen DetectionII-32
• Optic Interferometic Sensor for Detecting Biological Hazards and AttacksII-32
• Digital Signal Processing Technology (DSP) in BiosensorsII-33
• The World's Smallest BiosensorsII-33
• MiniMed Gains FDA Approval for Its Subcutaneous Glucose SensorII-33
• The Nanomachine: The World's Smallest MachineII-34
• Knoxville Cancer Survival Center Develops Laser-based SensorII-34
• Genetic Engineering Creates Biosensors to Clean EnvironmentII-34
• New Horizons Develops Immunoassay TestsII-34
• John Hopkins University Develops New Alfa-Toxin FabII-35
• Texas Instruments Develops a New Surface Plasmon Resonance SensorII-35
• A New Biosensor to Confirm PregnancyII-35
• Gold Biosensor to Detect CarcinogensII-35
• Drug Detecting BiosensorII-36
• Functional Genomics Technology Uses BiosensorsII-36

8.Focus on Select PlayersII-37

• Companies Developing Biosensor-Based DevicesII-37
• Abbott laboratoriesII-37
• I-Stat Corporation (USA)II-37
• Affinity Sensors (USA)II-38
• IAsys PlusII-38
• Bayer Diagnostics (USA)II-38
• Animas Corp (US)II-39
• Lifescan (USA)II-39
• Medtronic MiniMed Inc. (USA)II-39
• Roche Diagnostics (USA)II-39
• Leading Developers of Biosensor TechnologyII-40
• AgaMatrix Inc. (USA)II-40
• Cranfield Biotechnology Center (UK)II-40
• LifeSensors INC. (USA)II-40
• Nova Biomedical (USA)II-40
• Rheogene (USA)II-40
• SensAlyse Ltd. (UK)II-41

9.Global Market PerspectiveII-42

• Table 1: World Recent Past, Current & Future Market Analysis for Biosensors by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)II-42
• Table 2: World 10-Year Perspective for Biosensors by Geographic Region - Percentage Breakdown ofDollar Sales (*) for US, Canada, Japan, Europe,Asia-Pacific (excluding Japan) and Rest of World Marketsfor Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)II-42
• Table 3: World Recent Past, Current & Future Market Analysis for Medical Biosensors by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)II-43
• Table 4: World Recent Past, Current & Future Market Analysis for Medical Biosensors by Product Segments- Glucose Biosensors and Other Medical Biosensors Independently Analyzed with Annual Sales Figures (*) in US$ Millionfor Years 2000 through 2010) (includes corresponding Graph/Chart)II-43
• Table 5: World 10-Year Perspective for Medical Biosensors by Geographic Region - Percentage Breakdown ofDollar Sales (*) for US, Canada, Japan, Europe,Asia-Pacific (excluding Japan) and Rest of World Marketsfor Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)II-44
• Table 6: World 10-Year Perspective for Medical Biosensors by Product Segment- Percentage Breakdown of Dollar Sales (*) for Glucose Biosensors and Other Medical Biosensors Markets for Years 2000, 2005 & 2010 II-44
• Table 7: World Recent Past, Current & Future Market Analysis for Glucose Biosensors by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)II-45
• Table 8: World 10-Year Perspective for Glucose Biosensor by Geographic Region - Percentage Breakdown of Dollar Sales (*) for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)II-45
• Table 9: World Recent Past, Current & Future Market Analysis for Other Medical Biosensors by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)II-46
• Table 10: World 10-Year Perspective for Other Medical Biosensor by Geographic Region - Percentage Breakdown of Dollar Sales (*) for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)II-46
• Table 11: World Recent Past, Current & Future Market Analysis for Environmental Biosensors by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)II-47
• Table 12: World 10-Year Perspective for Environmental Biosensor by Geographic Region - Percentage Breakdown of Dollar Sales (*) for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets for Years 2000, 2005 & 2010. (includes corresponding Graph/Chart)II-47
• Table 13: World Recent Past, Current & Future Market Analysis for Other Biosensors by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)II-48
• Table 14: World 10-Year Perspective for Other Biosensor by Geographic Region - Percentage Breakdown of Dollar Sales (*) for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)II-48

III. MARKET

1.The United StatesIII-1

• A. Market AnalysisIII-1
• Other Facts and FiguresIII-1
• The US Diabetes Monitoring MarketIII-1
• Biosensors- Speeding Pathogen DetectionIII-1
• Product Launches/InnovationsIII-2
• Recent Industry Activity III-4
• Focus on Select Key PlayersIII-8
• Companies Developing Biosensor-Based DevicesIII-8
• Abbott LaboratoriesIII-8
• I-Stat CorporationIII-9
• Affinity SensorsIII-9
• Bayer DiagnosticsIII-10
• LifeScanIII-10
• Medtronic MiniMed IncIII-10
• Physiometrix IncIII-11
• Roche DiagnosticsIII-11
• Yellow Springs Instruments Inc.III-11
• Leading Developers of Biosensor TechnologyIII-11
• AgaMatrix Inc.III-11
• LifeSensors Inc.III-12
• Nova BiomedicalIII-12
• Oak Ridge National LaboratoryIII-12
• RHeogeneIII-13
• B. Market Estimates/ProjectionsIII-14
• Table15: US Recent Past, Current & Future Market Analysis for Biosensors by Product Segment - Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)III-14
• Table16: US 10-Year Perspective for Biosensors by Product Segment - Percentage Breakdown of Dollar Sales (*) for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-14

2.CanadaIII-15

• A. Market AnalysisIII-15
• Biosensor Researches in CanadaIII-15
• Microfluidic SystemsIII-15
• Biosensor InstitutionsIII-15
• B. Market Estimates/ProjectionsIII-16
• Table17: Canadian Recent Past, Current & Future Market Analysis for Biosensors by Product Segment - Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)III-16
• Table 18: Canadian 10-Year Perspective for Biosensors by Product Segment - Percentage Breakdown of Dollar Sales (*) for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-16

3.JapanIII-17

• A. Market AnalysisIII-17
• Strategic Corporate DevelopmentsIII-17
• B. Market Estimates/ProjectionsIII-18
• Table 19: Japanese Recent Past, Current & Future Market Analysis for Biosensors by Product Segment - Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)III-18
• Table 20: Japanese 10-Year Perspective for Biosensors by Product Segment - Percentage Breakdown of Dollar Sales (*) for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-18

4.EuropeIII-19

• A. Market AnalysisIII-19
• Market Trends & IssuesIII-19
• Environmental Monitoring... Diffusing in
• the Europe CountriesIII-19
• B. Market Estimates/ProjectionsIII-20
• Table 21: European Recent Past, Current & Future Market Analysis for Biosensors by Geographic Region - France, Germany, Italy, UK & Rest of Europe Markets Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010(includes corresponding Graph/Chart)III-20
• Table 22: European Recent Past, Current & Future Market Analysis for Biosensors by Product Segment - Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)III-20
• Table 23: European 10-Year Perspective for Biosensors by Geographic Region - Percentage Breakdown of Dollar Sales (*) for France, Germany, Italy, UK & Rest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-21
• Table 24: European 10-Year Perspective for Biosensors by Product Segment - Percentage Breakdown of Dollar Sales (*) for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-21
• Table25: European Recent Past, Current & Future Market Analysis for Medical Biosensors by Geographic Region - France, Germany, Italy, UK and Rest of Europe Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)III-22
• Table26: European Recent Past, Current & Future Market Analysis for Medical Biosensors by Product Segments- Glucose Biosensors and Other Medical Biosensors Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)III-22
• Table 27: European 10-Year Perspective for Medical Biosensors by Geographic Region - Percentage Breakdown of Dollar Sales (*) for France, Germany, Italy, UK andRest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-23
• Table 28: European 10-Year Perspective for Medical Biosensors by Product Segment- Percentage Breakdown of Dollar Sales (*) for Glucose Biosensors and Other Medical Biosensors Markets for Years2000, 2005 & 2010 III-23
• Table 29: European Recent Past, Current & Future Market Analysis for Glucose Biosensors by Geographic Region -France, Germany, Italy, UK and Rest of Europe Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)III-24
• Table 30: European 10-Year Perspective for Glucose Biosensor by Geographic Region - Percentage Breakdown of Dollar Sales (*) for France, Germany, Italy, UK and Rest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-24
• Table 31: European Recent Past, Current & FutureMarket Analysis for Other Medical Biosensors by Geographic Region - France, Germany, Italy,UK and Rest of Europe Independently Analyzedwith Annual Sales Figures (*) in US$ Million forYears 2000 through 2010 (includes corresponding Graph/Chart)III-25
• Table 32: European 10-Year Perspective forOther Medical Biosensor by Geographic Region - Percentage Breakdown of Dollar Sales (*) for France, Germany, Italy, UK and Rest of Europe Markets forYears 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-25
• Table 33: European Recent Past, Current & Future Market Analysis for Environmental Biosensors by Geographic Region - France, Germany, Italy, UK and Rest of Europe Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)III-26
• Table 34: European 10-Year Perspective for Environmental Biosensor by Geographic Region - Percentage Breakdown of Dollar Sales (*) for France, Germany, Italy, UK andRest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-26
• Table 35: European Recent Past, Current & Future Market Analysis for Other Biosensors by Geographic Region - France, Germany, Italy, UK and Rest of Europe Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)III-27
• Table 36: European 10-Year Perspective for Other Biosensor by Geographic Region - Percentage Breakdown of Dollar Sales (*) for France, Germany, Italy, UK andRest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-27

4a.FranceIII-28

• A. Market AnalysisIII-28
• B. Market Estimates/ProjectionsIII-28
• Table 37: French Recent Past, Current & Future Market Analysis for Biosensors by Product Segment - Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)III-28
• Table38: French 10-Year Perspective for Biosensors by Product Segment - Percentage Breakdown of Dollar Sales (*) for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-29

4b.GermanyIII-30

• A. Market AnalysisIII-30
• B. Market Estimates/ProjectionsIII-30
• Table 39: German Recent Past, Current & Future Market Analysis for Biosensors by Product Segment - Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years 2000 through 2010 (includes correspondingGraph/Chart)III-30
• Table 40: German 10-Year Perspective for Biosensors by Product Segment - Percentage Breakdown of Dollar Sales (*) for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-31

4c.ItalyIII-32

• A. Market AnalysisIII-32
• B. Market Estimates/ProjectionsIII-32
• Table 41: Italian Recent Past, Current & Future Market Analysis for Biosensors by Product Segment - Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets Independently Analyzed with Annual Sales Figures (*) in US$ Million for
• Years 2000 through 2010 (includes corresponding Graph/Chart)III-32
• Table 42: Italian 10-Year Perspective for Biosensors by Product Segment - Percentage Breakdown of Dollar Sales (*) for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-33

4d.The United KingdomIII-34

• A. Market AnalysisIII-34
• Future Outlook of Industrial BiosensorsIII-34
• Key PlayersIII-34
• SensAlyse Ltd.III-34
• Leading Developers of Biosensor Technology in UKIII-35
• Cranfield Biotechnology CenterIII-35
• Strategic Corporate DevelopmentsIII-35
• B. Market Estimates/ProjectionsIII-36
• Table 43: UK Recent Past, Current & Future Market Analysis for Biosensors by Product Segment - Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets Independently Analyzed with Annual Sales Figures (*) in US$ Million for Years2000 through 2010 (includes correspondingGraph/Chart)III-36
• Table 44: UK 10-Year Perspective for Biosensors by Product Segment - Percentage Breakdown of Dollar Sales (*) for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets for 2000, 2005 & 2010 (includes corresponding Graph/Chart)III-36

4e.Rest of EuropeIII-37

• A. Market AnalysisIII-37
• Focus on Select PlayersIII-37
• Biacore International AB (Sweden)III-37
• B. Market Estimates/ProjectionsIII-37
• Table 45: Rest of Europe Market for Biosensors - Recent Past, Current & Future Analysis by Product Segment for Medical Biosensors (Glucose Biosensors and OtherMedical Biosensors), Environmental Biosensors andOther Biosensors Markets Independently Analyzed withAnnual Sales Figures (*) in US$ Million for Years2000 through 2010 (includes correspondingGraph/Chart)III-37
• Table 46: Rest of Europe 10-Year Perspective for Biosensors by Product Segment - Percentage Breakdownof Dollar Sales (*) for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets for2000,2005 & 2010 (includes corresponding Graph/Chart)III-38

5.Asia-PacificIII-39

• A. Market AnalysisIII-39
• Historic ReviewIII-39
• CFTRI of India Announces New BiosensorIII-39
• CRC Develops an Extremely High SensorIII-39
• Nanomachine Developed in AustraliaIII-39
• B. Market Estimates/ProjectionsIII-40
• Table 47: Asia Pacific Market for Biosensors - Recent Past, Current & Future Analysis by Product Segment forMedical Biosensors (Glucose Biosensors and OtherMedical Biosensors), Environmental Biosensors and Other Biosensors Markets Independently Analyzed with Annual Sales Figures (*) in US$ Million forYears 2000 through 2010 (includes corresponding Graph/Chart)III-40
• Table 48: Asia Pacific 10-Year Perspective for Biosensors by Product Segment - Percentage Breakdown of Dollar Sales (*) for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets for 2000, 2005 & 2010
• (includes corresponding Graph/Chart)III-41

6.Rest of WorldIII-42

• A. Market AnalysisIII-42
• B. Market Estimates/ProjectionsIII-42
• Table 49:Rest of World Market for Biosensors - Recent Past, Current & Future Analysis by Product Segment for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets Independently Analyzed withAnnual Sales Figures (*) in US$ Million for Years2000 through 2010 (includes correspondingGraph/Chart)III-42
• Table 50: Rest of World 10-Year Perspective for Biosensors by Product Segment - Percentage Breakdown of Dollar Sales (*) for Medical Biosensors (Glucose Biosensors and Other Medical Biosensors), Environmental Biosensors and Other Biosensors Markets for 2000, 2005 & 2010
• (includes corresponding Graph/Chart)III-43

IV. COMPETITION

• 1. Abbott Laboratories (USA)IV-1
• Table 51: Quarterly Sales Analysis: 2003-2004(In US$ million)IV-3
• Table 52: Annual Sales Analysis by Segment:2003-2004 (In US$ million)IV-4
• Table 53: Annual Sales Analysis by GeographicalRegion: 2003-2004 (In US$ million)IV-4
• I-Stat Corporation (USA)IV-12
• 2.Abtech Scientific, Inc. (USA)IV-13
• 3.Affinity Sensors (USA)IV-16
• 4.Agamatrix, Inc. (USA)IV-17
• 5.Animas Corporation (USA)IV-18
• Table 54: First Quarter Sales Analysis: 2004-2005(Q1) (In US$ million)IV-18
• Table 55: Quarterly Sales Analysis: 2003-2004(In US $ million)IV-18
• Table 56: Annual Sales Analysis: 2003-2004(In US $ million)IV-19
• Table 57: Annual Sale Analysis by BusinessSegment: 2003-2004 (In US $ million)IV-19
• 6.Applied Biophysics, Inc. (USA)IV-21
• 7.Axela Biosensors, Inc. (Canada)IV-23
• 8.Bayer Healthcare - Diagnostics Division (USA)IV-24
• 9.Biacore International AB (Sweden)IV-27
• Table 58: First Quarter Sales Analysis:2004-2005 (Q1) (In SEK million)IV-28
• Table 59: Annual Sales Analysis: 2002-2003(In SEK million)IV-28
• Table 60: Annual Sales Analysis by GeographicRegion: 2003-2004 (In SEK million) IV-28
• Table 61: Quarterly Sales Analysis: 2003-2004(In SEK million) IV-28
• 10.BST Bio Sensor Technologie Gmbh (Germany)IV-30
• 11.Cranfield Biotechnology Center (UK)IV-31
• 12.Cytoplex Biosciences (USA)IV-34
• 13.Diametrics Medical, Inc. (USA)IV-35
• Table 62: Nine Months Sales Analysis:2003-2004 (Q3) (In US$ thousands)IV-35
• Table 63: Annual Sales Analysis: 2002-2003(In US$ thousands)IV-36
• Table 64: Quarterly Sales Analysis: 2002-2003(In US$ thousands)IV-36
• Table 65: Annual Sales Analysis by GeographicRegion: 2002-2003 (In US$ thousands)IV-36
• Table 66: Annual Sales Analysis by Product Segment:2002-2003 (In US$ thousands)IV-36
• 14.Digital Angel Corporation (USA)IV-37
• Table 67: First Quarter Sales Analysis:2004-2005 (Q1) (In US$ million)IV-38
• Table 68: Annual Sales Analysis: 2002-2004(In US$ million)IV-38
• Table 69: Quarterly Sales Analysis: 2003-2004(In US$ million)IV-39
• Table 70: Segment Wise Sales Analysis: 2003-2004(In US$ million)IV-39
• 15.Epocal, Inc. (Canada)IV-42
• 16.Gambro AB (Sweden)IV-43
• Table 71: Half Yearly Sales Analysis: 2004-2005 (H1)(In SEK million)IV-44
• Table 72: Half Yearly Sales Analysis by Segment:2004-2005(H1) (In SEK million)IV-44
• Table 73: Half Yearly Sales Analysis by Region:2004-2005 (H1) (In SEK million)IV-44
• Table 74: Annual Sales Analysis: 2003-2004(In SEK million)IV-45
• Table 75: Annual Sales Analysis by Segment:2003-2004 (In SEK million)IV-45
• Table 76: Annual Sales Analysis by Region:2003-2004 (In SEK million)IV-45
• 17.Genencor International, Inc. (USA)IV-47
• Table 77: Annual Sales Analysis: 2003-2004(In US$ million) IV-48
• Table 78: Annual Sales Analysis by Quarter:2003-2004 (In US$ million) IV-48
• 18.Imec (Belgium)IV-53
• 19.Lifescan, Inc. (USA)IV-54
• 20.Lifesensors, Inc. (USA)IV-59
• 21.Maxtec Inc., (USA)IV-60
• 22.M-Biotech, Inc. (USA)IV-61
• 23.Medtronic MiniMed, Inc. (USA)IV-62
• 24.Neurometrix, Inc. (USA)IV-63
• Table 79: First Quarter Sales Analysis:2004-2005 (Q1) (In US$ million)IV-63
• Table 80: First Quarter Sales Analysis by Segments:2004-2005 (Q1) (In US$ million)IV-64
• Table 81: Annual Sales Analysis: 2002-2004(In US$ million)IV-64
• Table 82: Annual Sales Analysis by BusinessSegments: 2003-2004 (In US$ million)IV-64
• Table 83: Quarterly Sales Analysis: 2003-2004(In US$ million)IV-64
• 25.Nova Biomedical (USA)IV-65
• 26.Oak Ridge National Laboratory (USA)IV-68
• 27.Oxford Biosensors, Ltd. (UK)IV-70
• 28.Pelikan Technologies, Inc. (USA)IV-71
• 29.Pinnacle Technology, Inc. (USA)IV-72
• 30.Primetech Corporation (Japan)IV-73
• 31.QinetiQ Group Plc (UK)IV-74
• Table 84: Annual Sales Analysis: 2003-2004(In £ million) IV-74
• Table 85: Annual Sales Analysis by Segment:2003-2004 (In £ million) IV-75
• Table 86: Annual Sales Analysis by Region:2003-2004 (In £ million) IV-75
• 32.Quantech (USA)IV-79
• 33.Remedios Ltd. (UK)IV-80
• 34.Rheogene, Inc. (USA)IV-82
• 35.Roche Diagnostics Corporation (USA)IV-84
• 36.SensAlyse Ltd. (UK)IV-88
• 37.Senslab GmbH (Germany)IV-89
• 38.Synthetic Blood International, Inc. (USA)IV-90
• 39.Universal Sensors, Inc. (USA)IV-91
• 40.Virtek Vision International, Inc. (Canada)IV-92
• Table 87: First Quarter Sales Comparison:2005-2006 (Q1) (In $ million)IV-93
• Table 88: Annual Sales Comparison by BusinessSegment: 2004-2005 (In $ million)IV-93
• Table 89: Quarterly Sales Comparison: 2004-2005(In $ millions)IV-93
• Table 90: Annual Sales Comparison by Product Line:2004-2005 (In $ millions)IV-93
• Table 91: Geographical Sales Comparison:2004-2005 (In $ million)IV-94
• 41.YSI Incorporated (USA)IV-95