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SUMMARY
In today' s world of Orthopedic Biomaterials, one thing that is expanding rapidly is the amount of new products in the research pipeline: stem cells,bone growth factors, gene therapy, synthetic bone fillers, bioactive implant coatings and biopolymers among others. The overall market is expected toenjoy healthy growth over the next 5 years, but the number one expansion story is in the bone growth factors and proteins segment, so calledorthobiologics. These products could grow from just a few percent of the orthopedic biomaterials market in 2002 to as much as 25-30% of the market by2007. This product segment also brings many new players to the market, namely pharmaceutical and biotech companies. The leading orthopedic companies are focused on what they do well, high-quality manufacturing and professional marketing and sales to increasemarket share and penetration. However, to be successful, they need a strong pipeline of new technology and products, the very ingredients that thebiotech industry brings to the table. But for their part, the biotech industry and small orthopedic technology companies don' t have the marketpresence or dedicated marketing and sales force to effectively compete with the leaders in the orthopaedic industry. The two sectors need each other. This comprehensive report examines the major factors in shaping the industry as we move toward the future. Understanding the driving clinical,technological, regulatory, and business factors will be crucial in strategic decisions about partners and markets, and for successful productcommercialization. The report covers two main market segments, and their respective sub-markets: (1) Bone Repair and Replacement, including Structural Bone Grafts,Bone Fillers, Implant Coatings, and Bone Growth Factors; and (2) Soft Tissue Repair, including Tissue Grafts, Tissue Regeneration, Knee LigamentFixation Devices, Meniscal Repair Devices, Shoulder Repair Devices, Synovial Fluid Replacement. Each section includes a look at the technologies andworldwide markets in 2002, as well as forecasts for the markets and new products through 2007. TABLE OF CONTENTS
1. EXECUTIVE SUMMARY2. BIOLOGIC MATERIALS Bone Replacement Materials- Autograft
- Allograft
- Demineralized Bone Matrix (DBM) Products
Bone Growth Factors- Transforming Growth Factor-beta (TGF- ?)
- Fibroblast Growth Factors (FGF)
- Allogeneic-Derived Growth Factors
- Blood-Extracted Growth Factors
- Recombinant Platelet-Derived Growth Factor (rhPDGF)
Tissue Replacement Materials- Chondrocyte Transplants
- Collagen Scaffolds
- Meniscal Allograft
- Ligamentous Autograft
- Ligamentous Allograft
- Tendinous Allograft
- Biologic Scaffolds and Patches
- Growth Factors and Gene Therapy
Synovial Fluid- Hyaluronic Acid
- Other Synovial Fluid Replacement Products
3. SYNTHETIC BIOMATERIALS Fixation Materials- Bioresorbable Polymers
- Structural Calcium Phosphates and Sulfates
- Composite Materials
- Calcium Phosphate Cements
Replacement Materials- Synthetic Bone Fillers
- Bioactive Implant Coatings
- Bioresorbable Polymer Scaffolds
4. BONE REPAIR AND REPLACEMENT MARKET Structural Bone Grafts- Indications and Procedures
- Leading Products
- Market Assessment
Bone Fillers- Indications and Procedures
- Leading Products
- Market Assessment
Implant Coatings- Indications and Procedures
- Leading Products
- Market Assessment
Bone Growth Factors- Indications and Procedures
- Leading Products
- Market Assessment
Bone Fixation Devices- Indications and Procedures
- Leading Products
- Market Assessment
5. TISSUE REPAIR AND REPLACEMENT MARKET Tissue Grafts- Indications and Procedures
- Leading Products
- Market Assessment
Tissue Regeneration- Indications and Procedures
- Leading Products
- Market Assessment
Knee Ligament Fixation Devices- Indications and Procedures
- Leading Products
- Market Assessment
Meniscal Repair Devices- Indications and Procedures
- Leading Products
- Market Assessment
Shoulder Repair Devices- Indications and Procedures
- Leading Products
- Market Assessment
Tendon Repair Devices- Indications and Procedures
- Leading Products
- Market Assessment
Synovial Fluid Replacement- Indications and Procedures
- Leading Products
- Market Assessment
6. COMPANY PROFILES - Aastrom Biosciences, Inc.
- Advanced Tissue Sciences, Inc.
- Allosource
- American Red Cross Tissue Services
- Arthrex, Inc.
- Biocomposites, Inc.
- Bionx Implants, Inc.
- Conmed Corporation
- Cryolife, Inc.
- Depuy/Johnson & Johnson
- Dj Orthopedics
- Etex Corporation
- Exactech, Inc.
- Gensci Regeneration Sciences, Inc.
- Genzyme Biosurgery, Inc.
- Implex
- Integra Lifesciences Holdings Corporation
- Interpore Cross International, Inc.
- Isotis, N.V.
- Kinamed
- Li Medical
- Lifecell Corporation
- Linvatec/Conmed Corp.
- Macropore
- Medtronic, Inc.
- Mitek/Ethicon/Johnson & Johnson
- Musculoskeletal Transplant Foundation
- Neucoll, Inc.
- Northwest Tissue Center
- Ohio Valley Tissue & Skin Center
- Orquest, Inc.
- Orthovita, Inc.
- Osiris Therapeutics
- Osteotech, Inc.
- Pacific Coast Tissue Bank
- Regen Biologics, Inc.
- Regeneration Technologies, Inc.
- Smith & Nephew, Plc
- Stryker Biotech
- Stryker Endoscopy
- Stryker Howmedica/Osteonics
- Sulzer Orthopaedics
- Synthes-Stratec, Inc.
- Tutogen Medical, Inc.
- W.L. Gore & Associates
- Wright Medical Technology
- Zimmer
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