Current Medical Technologies, Applications & Market Opportunities in Nanotechnology & MEMS, 2002-2012

SUMMARY

While much of the enormous potential in nanotechnology and micro-electro-mechanical systems (MEMS) is at least a few years from beginning tomaterialize, the existence of substantial current revenue, current profits and a wide array of current activity demands scrutiny now by any entitiesseeking to truly capitalize on this market.

The report on nanotechnology and MEMS is a detailed market and technology assessment and forecast of the products and technologies involved in themedical application of MEMS and nanotechnology. The Report details the current and emerging products, technologies and markets in the medical use ofMEMS and nanotechnology. Specifically, the report comprehensively details the clinical applications, the status of products & technologies underdevelopment, the current/forecast market for each major application, the current or likely competitors and their positions in the market, and theopportunities for current or hopeful competitors in this field.

TABLE OF CONTENTS

Section 1: MEMS AND NANOTECHNOLOGY IN MEDICINE

1.1 Introduction

1.1.1 MEMS and Nanotechnology Markets

1.1.1.1 The Nanotech Market Outlook

1.1.1.2 The MEMS Market

1.1.2 Comparison of Medical Applications using Micro- and Nano- Technologies

1.2 Diversity of Micro- and Nano- Medical Technologies

1.2.1 Some Examples of Medical Applications of MEMS and other Microtechnologies

1.2.1.1 MEMS, Lab on a Chip, and Microfluidics

1.2.1.2 Prosthetics made of MEMS and Nanomaterials

1.2.1.3 Micro- and Nano-Manipulation

1.2.1.4 Medical Applications of MEMS Sensors

1.2.1.5 Confocal Microscope Endoscope

1.2.2 Survey of Nanostructures with Medical Applications

1.2.2.1 Nanofiltration Membranes

1.2.2.2 Quantum Dots

1.2.2.3 Nanoparticles and Nanowires

1.2.2.4 Drug Delivery with Nanoparticles

1.2.2.5 Antibacterial and Antiviral Nanoparticles

1.2.2.6 Dendrimers

1.2.2.7 Nanoshells

1.2.2.8 Liposome Nanoparticles

1.2.2.9 Nanoemulsions

1.2.2.10 Fullerenes

1.2.2.11 Carbon Nanotubes

1.2.2.12 Polymeric Micelles

Section 2: MEDICAL MEMS

2.1 Some Examples of Medical Applications of MEMS

2.1.1 Introduction

2.1.2 Measure Pressure Inside Arteries

2.1.3 Smart Surgical Tools

2.1.4 Wearable Drug Infusion Systems

2.2 MEMS Sensors and Biosensors

2.2.1 MEMS Sensors

2.2.1.1 MEMS Pressure Sensor

2.2.1.2 MEMS Accelerometers

2.2.1.3 Expanding Medical Applications for MEMS Sensors

2.2.2 Biosensors

2.3 MEMS Fabrication Technologies

2.3.1 Historical

2.3.2 Surface Milling

2.3.3 Wet Bulk Micromachining

2.3.4 Surface Micromachining

2.3.5 LIGA Fabrication

2.3.6 EFAB MEMS Fabrication

2.4 Laboratory Applications

2.4.1 MEMS, Microfluidics and Biochips

2.4.2 Cell-Sorting and Manipulation

2.4.3 MEMS Based PCR Chip

2.4.4 Blood-Analysis System on a Chip

2.5 MEMS Medical Applications

2.5.1 MEMS Drug Delivery

2.5.1.1 Silicon Microteeth Inject Individual Blood Cells

2.5.1.2 MEMS Infusion Pumps

2.5.1.3 MEMS Pump used to Administer Insulin

2.5.1.4 Thermocapillary Pump

2.5.2 Surgery Aids

2.5.2.1 MEMS-based Orthopedic Implants

2.5.2.2 Smart Surgical Scalpels

2.5.3 Endoscopic Microscope

2.5.3.1 Micromirrors Robust Enough for Endoscopes

2.5.3.2 Capsule Endoscope Receives FDA Approval

Section 3: NANOMEDICINE

3.1 Introduction

3.2 Building Nanotechnology

3.2.1 Tools

3.2.2 Nanotechnology Manufacturing

3.2.2.1 Self-assembly

3.2.2.2 Soft Lithography

3.2.2.3 Dip-pen Nanolithography

3.3 Nanotechnology Medical Applications moving to Commercialization

3.3.1 Nanoscreen Protects Implanted Tissues

3.3.2 Nanoshells

3.3.3 Diagnostics with Quantum Dots

3.3.4 Magnetically Responsive Nanoparticles

3.3.5 Self-generating Nanotubes with 'Dial-up' Properties

3.3.6 Nanoparticles Aimed at Drug Delivery

3.3.6.1 Life-Size Challenges to Developing Nano-Delivery

3.3.6.2 Bringing Drug Delivery to Market

3.3.6.3 Cyclic Peptides

3.3.6.4 Quantum Dots

3.3.6.5 Liposomes

3.4 The Political and Ethical Landscape

3.4.1 Public Discussion Is Essential

3.4.2 How Safe is Nanotech

3.4.3 People want Power Over Technology

3.4.4 National Nanotechnology Initiative (NNI)

Section 4: MEMS AND NANOTECHNOLOGY COMPANIES, CONTACTS AND PATENTS

4.1 Profiles of MEMS and Nanotechnologies Companies Specializing in Medical Applications

4.1.1 3D Matrix Inc

4.1.2 3rdTech, Inc.

4.1.3 Aclara BioSciences, Inc.

4.1.4 Acusphere, Inc.

4.1.5 Advectus Life Sciences Inc.

4.1.6 Albany NanoTech

4.1.7 Alcove Surfaces GmbH

4.1.8 ALZA Corporation

4.1.9 Analog Devices, Inc.

4.1.10 Applied NanoSystems

4.1.11 Ardesta

4.1.12 Argonide Corporation

4.1.13 Ball Semiconductor, Inc.

4.1.14 Baxter International Inc.

4.1.15 Becton, Dickinson and Company

4.1.16 BioDelivery Sciences International, Inc.

4.1.17 BioForce Nanosciences, Inc.

4.1.18 Bioplex Corporation

4.1.19 BioTrove, Inc.

4.1.20 C Sixty Inc.

4.1.21 CardioMEMS, Inc.

4.1.22 Cardiosonix

4.1.23 CAS Medical Systems, Inc.

4.1.24 The Center For Biological and Environmental Nanotechnololgy

4.1.25 Center for Nanofabrication and Molecular Self-Assembly

4.1.26 Centerpulse Spine-Tech

4.1.27 Cepheid

4.1.28 ChipRx, Inc.

4.1.29 Colibrys USA

4.1.30 Computer Motion, Inc.

4.1.31 Corning Intellisense

4.1.32 Coventor, Inc.

4.1.33 Daji Biosciences, Inc.

4.1.34 Debiotech S.A.

4.1.35 European NanoBusiness Association

4.1.36 Evident Technologies

4.1.37 FeRx Incorporated

4.1.38 Flamel Technologies S.A.

4.1.39 Fraunhofer Institute for Silicon Technology

4.1.40 General Nanotechnology

4.1.41 Given Imaging Inc.

4.1.42 Gyros US, Inc.

4.1.43 i-STAT Corporation

4.1.44 iMEDD, Inc.

4.1.45 Insert Therapeutics, Inc.

4.1.46 Institute of Nanotechnology

4.1.47 Integrated Sensing Systems, Inc. (ISSYS)

4.1.48 Inverness Medical Innovations, Inc.

4.1.49 Kumetrix, Inc.

4.1.50 Laser- und Medizin-Technologie GmbH, Berlin

4.1.51 LaunchCyte, LLC

4.1.52 Light Sciences Corporation

4.1.53 Lucas NovaSensor

4.1.54 Micralyne Inc.

4.1.55 MicroCHIPS, Inc.

4.1.56 Micronics, Inc.

4.1.57 NanoBio Corporation

4.1.58 NanoBusiness Alliance

4.1.59 NanoCarrier

4.1.60 Nanogen, Inc.

4.1.61 NanoInk, Inc.

4.1.62 Nanolayers

4.1.63 NanoMatrix, Inc.

4.1.64 Nanoprobes, Incorporated

4.1.65 Nanoptics, Inc.

4.1.66 NanoScale Materials Inc.

4.1.67 Nanospectra Biosciences, Inc.,

4.1.68 Nanosphere, Inc.

4.1.69 Nanostream, Inc.

4.1.70 Nanosys, Inc.

4.1.71 Nanotherapeutics, Inc.

4.1.72 Neoprobe Corporation

4.1.73 Optobionics Corporation

4.1.74 OraPharma, Inc.

4.1.75 Oxonica Limited

4.1.76 pSivida Limited

4.1.77 Quantum Dot Corp.

4.1.78 Sandia National Laboratories, New Mexico

4.1.79 Targesome, Inc.

4.1.80 Tecan U.S., Inc.

4.1.81 TheraFuse, Inc.

4.1.82 Utah Medical Products, Inc.

4.1.83 Verimetra, Inc.

4.1.84 Zimmer, Inc.

Appendix 1: List of companies

Appendix 2: Recent U.S. Patents in MEMS Medicine andNanomedicine

List of Exhibits

Exhibit 1-1: Comparison of Nanotechnology and MEMS

Exhibit 1-2: Commercially Established MEMS Products

Exhibit 1-3: Results the NanoBusiness Alliance (NBA) Industry Association Poll

Exhibit 1-4: Total Nanotechnology Market, Worldwide Forecast

Exhibit 1-5: Distribution of Revenue among Nanotechnology Applications Market Segments — Worldwide Estimate

Exhibit 1-6: Summary of Recent Information Released by MEMS Industry Group (MIG)

Exhibit 1-7: Total MEMS Worldwide Forecast

Exhibit 1-8: Two State-of-the-art MEMS Pressure Sensors

Exhibit 1-9: Representation of the Structure of a Dendrimer at the Earlier Stages of Growth

Exhibit 1-10: Illustration of Dendrimers Floating with Cells

Exhibit 1-11: Growth stages of gold nanoshells around silica nanoparticles

Exhibit 1-12: C60-Fullerene at 153 Kelvin.

Exhibit 1-13: Illustration of the Relative Diameters of a Micelle and Other Structures

Exhibit 2-1: MEMS for use in Medical Applications, Worldwide Forecast

Exhibit 2.2:Estimated Medical Microsystems Sales in 2002 – MEMS and other Microsystems, Worldwide

Exhibit 2-3: Verimetra' s concept of the "Data Knife"

Exhibit 2-3: MEMS-based Medical Sensors, U.S. Forecast

Exhibit 2-4: Biosensor Market, Worldwide Forecast

Exhibit 2-5: Biochip Market — Microarrays, Microfluidics, etc.,Worldwide Forecast

Exhibit 2-7. Sandia' s Microteeth

Exhibit 2-8: MEMS-Based Microinjection Needles

Exhibit 2-9: Given Imaging' s Capsule Endoscope

Exhibit 3-1: Nanoporous Membrane in an Implantable Capsule

Exhibit 3-2: The Fenniri Scaffold

Exhibit 3-3: A Self-assembled Rosette Nanotube and its Mirror

Exhibit 3-4: Fullerene-based HIV Drug

Exhibit 3-5: Selected Companies Illustrating Various Nanotechnology Drug Delivery Technologies

Exhibit 3-6: Total Drug Delivery Technology, U.S. Forecast

Exhibit 3-7: Nanotechnology-based Drug Delivery, U.S. Market

Exhibit 4-1: Online Nanotechnology Resources

Exhibit 4-2: Lists the Assignee Organizations for the Patents in APPENDIX 2.

Exhibit 4-3: Selected Organizations Issued U.S. Patents for Medical MEMS or Nanomedicine Applications During the Past Two Years.