Protein Crystallography Strategic Opportunities

SUMMARY

Diversified Scientific provides CrystalScore, automated image acquisition andanalysis designed for protein crystallization plates.

Technology

• The database software provides automated hardware control, image and dataarchiving, image processing, a searchable database, and surface plotting ofexperimental data.

Stage of Development

CrystalScore was one of the first fully automated systems for imaging andanalyzing crystallization plates. A US Patent has been issued for a method foracquiring, storing and analyzing crystal images.

Competitive Assessment

• STRENGTHS
  • Solid installed base of users
  • Issued US Patent on technology
  • Relatively low cost system
• WEAKNESSES
  • Lack of automation capabilities
  • No incubated storage offered
• OPPORTUNITIES
  • Partner with automated plate storage provider
• THREATS
  • Complete crystallization system providers
  • Microscope systems providers

TABLE OF CONTENTS

Chapter 1. Executive Summary

Chapter 2. Introduction to Protein Crystallography

Protein Crystallography: The Concept

Crystallization Techniques

Crystallization Screening is a Sampling Problem

Protein Crystallography: Motif to Crystal

A Small Crystal

Protein Crystallography: An Approach to Crystallization

Protein Crystallography: Diffraction Set-Up

Protein Crystallography: Crystal to Structure

Protein Crystallography: Sample Data

Why Crystallography in Drug Design

Cost and Timeline of Drug Development

Advantages of Crystallography in Drug Design

Fundamental Protein Crystallography Challenges

Why High-Throughput Protein Crystallography Now?

Structural Genomics Progress Statistics

Caveats and Conclusions from targetDB

Both Protein Expression and Crystallization Are Comparable High-ThroughputScreening Tasks

Basic Overview of High-Throughput Protein Crystallization

Extended View of High-Throughput Protein Crystallography

Customized High-Throughput Protein Crystallography Automation

An Example of Customized High-Throughput Protein CrystallographyAutomation

Automation and Approaches for High-Throughput Protein Crystallography

Demands on Liquid Handling in Crystallization

Basic Two-Stage Set-up?Cocktail Preparation

Second Stage: Crystallization Plate Set-up

Combination: 96+8 Innovadyne Dispenser

Multi-Purpose Batch Robot: IMPAX, ORYX

Multiple Stages Needs Plate Transfer and Storage

State of the Market, June 2004: Technology Trends?Drop Size

State of the Market, June 2004: Technology Trends?Software

Summary of Bottlenecks in the Automation of Protein Crystallography

Applications and Limitations of Protein Crystallography

Chapter 3. Interviews With Experts

Chapter 4. Market Analysis

State of the Market, June 2004: Market Trends

State of the Crystallography Space, June 2004: Market Trends

State of the Crystallography Space, June 2004: Growth Trends

Market Evolution: Qualitative Depiction

Protein Crystallography Competitive Landscape

Summary of Market Opportunities

Chapter 5. Competitive Landscape

Accelrys

ActiveSight

Astex Technology, Ltd.

Bruker Biosciences

Crystal Research

DataCentric Automation/Kendro

DeCode Genetics

Diversified Scientific

Douglas Instruments, Ltd.

Fluidigm

Formulatrix

Genomic Solutions, Inc.

Gilson

Hamilton Company

Hampton Research

Innovadyne Technologies, Inc.

Matrix Technologies

Molecular Dimensions

Oxford Diffraction

Rigaku/MSC

RoboDesign International, Inc.

Shamrock Structures

Structural GenomiX

Syrrx

Tecan AG

TriTek Corporation

TTP LabTech, Ltd.

Veeco Instruments

Appendix I. Methodology